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miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2

Esophageal cancer is the eighth most common malignant tumor worldwide, of which esophageal squamous cell carcinoma (ESCC) is the dominant histological subtype. A drug shortage for ESCC therapy triggered us to explore the roles of fibroblast growth factor receptor 2 (FGFR2) and its upstream regulator...

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Autores principales: Li, Xiaoyan, Nie, Changjun, Tian, Baoqing, Tan, Xuan, Han, Wei, Wang, Jiakang, Jin, Yuan, Li, Yadan, Guan, Xinyuan, Hong, An, Chen, Xiaojia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743296/
https://www.ncbi.nlm.nih.gov/pubmed/31523191
http://dx.doi.org/10.7150/ijbs.32429
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author Li, Xiaoyan
Nie, Changjun
Tian, Baoqing
Tan, Xuan
Han, Wei
Wang, Jiakang
Jin, Yuan
Li, Yadan
Guan, Xinyuan
Hong, An
Chen, Xiaojia
author_facet Li, Xiaoyan
Nie, Changjun
Tian, Baoqing
Tan, Xuan
Han, Wei
Wang, Jiakang
Jin, Yuan
Li, Yadan
Guan, Xinyuan
Hong, An
Chen, Xiaojia
author_sort Li, Xiaoyan
collection PubMed
description Esophageal cancer is the eighth most common malignant tumor worldwide, of which esophageal squamous cell carcinoma (ESCC) is the dominant histological subtype. A drug shortage for ESCC therapy triggered us to explore the roles of fibroblast growth factor receptor 2 (FGFR2) and its upstream regulator miR-671-5p in ESCC progression. We compared the levels of FGFR2 and miR-671-5p between human ESCC tissues and their matched normal esophageal tissues and found an association between higher levels of FGFR2 and lower levels of miR-671-5p in ESCC tissues. High levels of FGFR2 resulted in the activation of the ERK and AKT pathways and a promotion of ESCC progression. High levels of miR-671-5p specifically reduced the expression of FGFR2 and suppressed ESCC progression in both in vitro and in vivo models. Therefore, suppressing FGFR2 and enhancing miR-671-5p expression may be the right approaches for ESCC therapy.
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spelling pubmed-67432962019-09-14 miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2 Li, Xiaoyan Nie, Changjun Tian, Baoqing Tan, Xuan Han, Wei Wang, Jiakang Jin, Yuan Li, Yadan Guan, Xinyuan Hong, An Chen, Xiaojia Int J Biol Sci Research Paper Esophageal cancer is the eighth most common malignant tumor worldwide, of which esophageal squamous cell carcinoma (ESCC) is the dominant histological subtype. A drug shortage for ESCC therapy triggered us to explore the roles of fibroblast growth factor receptor 2 (FGFR2) and its upstream regulator miR-671-5p in ESCC progression. We compared the levels of FGFR2 and miR-671-5p between human ESCC tissues and their matched normal esophageal tissues and found an association between higher levels of FGFR2 and lower levels of miR-671-5p in ESCC tissues. High levels of FGFR2 resulted in the activation of the ERK and AKT pathways and a promotion of ESCC progression. High levels of miR-671-5p specifically reduced the expression of FGFR2 and suppressed ESCC progression in both in vitro and in vivo models. Therefore, suppressing FGFR2 and enhancing miR-671-5p expression may be the right approaches for ESCC therapy. Ivyspring International Publisher 2019-07-21 /pmc/articles/PMC6743296/ /pubmed/31523191 http://dx.doi.org/10.7150/ijbs.32429 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Li, Xiaoyan
Nie, Changjun
Tian, Baoqing
Tan, Xuan
Han, Wei
Wang, Jiakang
Jin, Yuan
Li, Yadan
Guan, Xinyuan
Hong, An
Chen, Xiaojia
miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title_full miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title_fullStr miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title_full_unstemmed miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title_short miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
title_sort mir-671-5p blocks the progression of human esophageal squamous cell carcinoma by suppressing fgfr2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743296/
https://www.ncbi.nlm.nih.gov/pubmed/31523191
http://dx.doi.org/10.7150/ijbs.32429
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