CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin

Deletion of Chromosome 3p is one of the most frequently detected genetic alterations in nasopharyngeal carcinoma (NPC). We reported the role of a novel 3p26.3 tumor suppressor gene (TSG) CHL1 in NPC. Down-regulation of CHL1 was detected in 4/6 of NPC cell lines and 71/95 (74.7%) in clinical tissues....

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Detalles Bibliográficos
Autores principales: Chen, Juan, Jiang, Chen, Fu, Li, Zhu, Cai-Lei, Xiang, Yan-Qun, Jiang, Ling-Xi, Chen, Qian, Liu, Wai Man, Chen, Jin-Na, Zhang, Li-Yi, Liu, Ming, Chen, Chao, Tang, Hong, Wang, Bo, Tsao, Sai Wah, Kwong, Dora Lai-Wan, Guan, Xin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743306/
https://www.ncbi.nlm.nih.gov/pubmed/31523184
http://dx.doi.org/10.7150/ijbs.34785

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