Cargando…

Risk assessment of FLT3 and PAX5 variants in B-acute lymphoblastic leukemia: a case–control study in a Pakistani cohort

AIMS: B-cell acute lymphoblastic leukemia (B-ALL) is amongst the most prevalent cancers of children in Pakistan. Genetic variations in FLT3 are associated with auto-phosphorylation of kinase domain that leads to increased proliferation of blast cells. Paired box family of transcription factor (PAX5)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khalid, Ammara, Aslam, Sara, Ahmed, Mehboob, Hasnain, Shahida, Aslam, Aimen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743442/ https://www.ncbi.nlm.nih.gov/pubmed/31565544 http://dx.doi.org/10.7717/peerj.7195

Ejemplares similares

Implications of ACMG guidelines to identify high-risk acute lymphoblastic leukemia patients with hereditary cancer susceptibility syndromes (HCSS) in a highly consanguineous population
por: Aslam, Sara, et al.
Publicado: (2021)

Pharmacogenetics of induction therapy-related toxicities in childhood acute lymphoblastic leukemia patients treated with UKALL 2003 protocol
por: Aslam, Sara, et al.
Publicado: (2021)

Novel Genetic Variations in Acute Myeloid Leukemia in Pakistani Population
por: Shahid, Saba, et al.
Publicado: (2020)

Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study
por: Shabana,, et al.
Publicado: (2015)

Diversity of clinical phenotypes in a cohort of Han Chinese patients with PAX6 variants
por: Huang, Lijuan, et al.
Publicado: (2023)

PAX5 alterations in B-cell acute lymphoblastic leukemia
por: Jia, Zhilian, et al.
Publicado: (2022)

The C1431T polymorphism of peroxisome proliferator activated receptor γ (PPARγ) is associated with low risk of diabetes in a Pakistani cohort
por: Butt, Huma, et al.
Publicado: (2016)

Validations of Top and Novel Susceptibility Variants in All-Age Chinese Patients With Acute Lymphoblastic Leukemia
por: Liao, Fei, et al.
Publicado: (2020)

The Role of ARID5B in Acute Lymphoblastic Leukemia and Beyond
por: Wang, Peiqi, et al.
Publicado: (2020)

Identification of genetic basis of obesity and mechanistic link of genes and lipids in Pakistani population
por: Shabana,, et al.
Publicado: (2018)

PAX5 fusion genes in acute lymphoblastic leukemia: A literature review
por: Fouad, Fatma Mohamed, et al.
Publicado: (2023)

Genetic studies in the Pakistani population reveal novel associations with ventricular septal defects (VSDs)
por: Sarwar, Sumbal, et al.
Publicado: (2023)

FLT3 Mutations in Acute Myeloid Leukemia: Unraveling the Molecular Mechanisms and Implications for Targeted Therapies
por: Jalte, Meryem, et al.
Publicado: (2023)

Lack of FLT3-ITD in Tunisian childhood acute lymphoblastic leukemia
por: Frikha, Rim, et al.
Publicado: (2022)

Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain
por: Fabian, Peter, et al.
Publicado: (2015)

Study of variants associated with ventricular septal defects (VSDs) highlights the unique genetic structure of the Pakistani population
por: Sarwar, Sumbal, et al.
Publicado: (2022)

Detection of De Novo PAX2 Variants and Phenotypes in Chinese Population: A Single-Center Study
por: Xiong, Hua-Ying, et al.
Publicado: (2022)

PAX Genes in Cancer; Friends or Foes?
por: Li, Caiyun G., et al.
Publicado: (2012)

Association of variable number of tandem repeats (VNTR) and T941G polymorphism of monoamine oxidase (MAO-A) gene with aggression in Pakistani subjects
por: Sarwar, Sumbal, et al.
Publicado: (2021)

Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia
por: Li, Zhenhua, et al.
Publicado: (2021)

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia
por: Heltemes-Harris, Lynn M., et al.
Publicado: (2011)

A Novel Homozygous Frameshift Variant in XYLT2 Causes Spondyloocular Syndrome in a Consanguineous Pakistani Family
por: Kausar, Mehran, et al.
Publicado: (2019)

Genotype-phenotype pattern analysis of pathogenic PAX9 variants in Chinese Han families with non-syndromic oligodontia
por: Ren, Jiabao, et al.
Publicado: (2023)

Cytogenetic Profile and FLT3 Gene Mutations of Childhood Acute Lymphoblastic Leukemia
por: Alkhayat, Nawaf, et al.
Publicado: (2017)

Paired-Box Gene 8 (PAX8) and Its Association With Epithelial Carcinomas
por: Khizer, Khalid, et al.
Publicado: (2021)

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia
por: Liu, Grace J., et al.
Publicado: (2014)

Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping
por: Jean, Jeffrey, et al.
Publicado: (2022)

PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia
por: Li, Yizhen, et al.
Publicado: (2022)

The First Report of a Missense Variant in RFX2 Causing Non-Syndromic Tooth Agenesis in a Consanguineous Pakistani Family
por: Khan, Sher Alam, et al.
Publicado: (2022)

Case Report: The compound heterozygotes variants in FLT4 causes autosomal recessive hereditary lymphedema in a Chinese family
por: Xiang, Qinqin, et al.
Publicado: (2023)

Frequency and prognostic impact of PAX5 p.P80R in pediatric acute lymphoblastic leukemia patients treated on an AIEOP‐BFM acute lymphoblastic leukemia protocol
por: Jung, Mareike, et al.
Publicado: (2020)

PAX5 and TDT-Negative B-Acute Lymphoblastic Leukemia with Unusual Genetic Mutations: A Case Report
por: Aladily, Tariq N., et al.
Publicado: (2022)

Genotype-Phenotype of Isolated Foveal Hypoplasia in a Large Cohort: Minor Iris Changes as an Indicator of PAX6 Involvement
por: Jiang, Yi, et al.
Publicado: (2021)

Biochemical, serological, and genetic aspects related to gene HLA‐DQB1 and its association with type 1 diabetes mellitus (T1DM)
por: Singh, Gur Charn, et al.
Publicado: (2020)

Association between risk factors and migraine in Pakistani females
por: Razzak, Nida, et al.
Publicado: (2023)

A Novel Nonsense Mutation in FERMT3 Causes LAD-III in a Pakistani Family
por: Shahid, Saba, et al.
Publicado: (2019)

Multilocus Genotypes of Relevance for Drug Metabolizing Enzymes and Therapy with Thiopurines in Patients with Acute Lymphoblastic Leukemia
por: Stocco, Gabriele, et al.
Publicado: (2013)

Clinical presentation of autoimmune hepatitis in Pakistani children
por: Somroo, Ghous Bux, et al.
Publicado: (2018)

Clinical and Genetic Characteristics of IKZF1 Mutation in Chinese Children With B-Cell Acute Lymphoblastic Leukemia
por: Zhang, Jingying, et al.
Publicado: (2022)

Identification of Potential Signatures and Their Functions for Acute Lymphoblastic Leukemia: A Study Based on the Cancer Genome Atlas
por: Wang, Weimin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nng76ausqgajdn1e6m749omt0i