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Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers

Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression...

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Autores principales: Hu, Jiali, Li, Ke, Li, Zhanghuan, Gao, Chao, Guo, Fei, Wang, Yingmei, Xue, Fengxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743626/
https://www.ncbi.nlm.nih.gov/pubmed/31565477
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0062
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author Hu, Jiali
Li, Ke
Li, Zhanghuan
Gao, Chao
Guo, Fei
Wang, Yingmei
Xue, Fengxia
author_facet Hu, Jiali
Li, Ke
Li, Zhanghuan
Gao, Chao
Guo, Fei
Wang, Yingmei
Xue, Fengxia
author_sort Hu, Jiali
collection PubMed
description Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical, and endometrial cancer. In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels. Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers. An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.
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spelling pubmed-67436262019-09-27 Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers Hu, Jiali Li, Ke Li, Zhanghuan Gao, Chao Guo, Fei Wang, Yingmei Xue, Fengxia Cancer Biol Med Review Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical, and endometrial cancer. In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels. Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers. An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers. Chinese Anti-Cancer Association 2019-08 /pmc/articles/PMC6743626/ /pubmed/31565477 http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0062 Text en Copyright 2019 Cancer Biology & Medicine http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Hu, Jiali
Li, Ke
Li, Zhanghuan
Gao, Chao
Guo, Fei
Wang, Yingmei
Xue, Fengxia
Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title_full Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title_fullStr Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title_full_unstemmed Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title_short Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
title_sort sex-determining region y box-containing genes: regulators and biomarkers in gynecological cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743626/
https://www.ncbi.nlm.nih.gov/pubmed/31565477
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0062
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