Executable pathway analysis using ensemble discrete-state modeling for large-scale data

Pathway analysis is widely used to gain mechanistic insights from high-throughput omics data. However, most existing methods do not consider signal integration represented by pathway topology, resulting in enrichment of convergent pathways when downstream genes are modulated. Incorporation of signal...

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Detalles Bibliográficos
Autores principales: Palli, Rohith, Palshikar, Mukta G., Thakar, Juilee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743792/
https://www.ncbi.nlm.nih.gov/pubmed/31479446
http://dx.doi.org/10.1371/journal.pcbi.1007317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743792/
https://www.ncbi.nlm.nih.gov/pubmed/31479446
http://dx.doi.org/10.1371/journal.pcbi.1007317

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