Inhibition of Notch signaling rescues cardiovascular development in Kabuki Syndrome

Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenit...

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Detalles Bibliográficos
Autores principales: Serrano, Maria de los Angeles, Demarest, Bradley L., Tone-Pah-Hote, Tarlynn, Tristani-Firouzi, Martin, Yost, H. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743796/
https://www.ncbi.nlm.nih.gov/pubmed/31479440
http://dx.doi.org/10.1371/journal.pbio.3000087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743796/
https://www.ncbi.nlm.nih.gov/pubmed/31479440
http://dx.doi.org/10.1371/journal.pbio.3000087

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