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Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis

BACKGROUND/AIMS: The validity of (13)C-urea breath test ((13)C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of (13)C-Urea breath test after H. pylori eradication therapy in a region where a...

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Autores principales: Kwon, Yong Hwan, Kim, Nayoung, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Lee, Dong Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743802/
https://www.ncbi.nlm.nih.gov/pubmed/30970440
http://dx.doi.org/10.5009/gnl18398
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author Kwon, Yong Hwan
Kim, Nayoung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
author_facet Kwon, Yong Hwan
Kim, Nayoung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
author_sort Kwon, Yong Hwan
collection PubMed
description BACKGROUND/AIMS: The validity of (13)C-urea breath test ((13)C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of (13)C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common. METHODS: In this prospective study, H. pylori-positive patients received (13)C-UBT after H. pylori eradication regimen. They were classified into citric acid group and control group. To determine diagnostic accuracy of (13)C-UBT, patients were offered invasive methods. RESULTS: A total of 1,207 who successfully took H. pylori-eradication regimen received UBT. They were assigned into the citric acid group (n=562) and the control group (n=645). The mean (13)C-UBT value of the citric acid group was 10.3±26.4‰, which was significantly (p<0.001) higher than that of that control group (5.1‰±12.6‰). Of these patients 122 patients were evaluated by endoscopic biopsy methods. Based on invasive tests, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of (13)C-UBT for the citric acid group were 83.3%, 91.7%, 81.3%, 55.0%, and 97.5%, respectively. Those of the control group were 87.7%, 90.9%, 88.2%, 62.5%, and 97.8%, respectively. They were not significantly different between the two groups. Although the presence of gastric atrophy and intestinal metaplasia (IM) decreased the accuracy, the decrease was not significant. CONCLUSIONS: In a country with high prevalence of atrophic gastritis or IM, false positivity remained common despite the use of citric acid in (13)C-UBT.
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spelling pubmed-67438022019-09-20 Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis Kwon, Yong Hwan Kim, Nayoung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Gut Liver Original Article BACKGROUND/AIMS: The validity of (13)C-urea breath test ((13)C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of (13)C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common. METHODS: In this prospective study, H. pylori-positive patients received (13)C-UBT after H. pylori eradication regimen. They were classified into citric acid group and control group. To determine diagnostic accuracy of (13)C-UBT, patients were offered invasive methods. RESULTS: A total of 1,207 who successfully took H. pylori-eradication regimen received UBT. They were assigned into the citric acid group (n=562) and the control group (n=645). The mean (13)C-UBT value of the citric acid group was 10.3±26.4‰, which was significantly (p<0.001) higher than that of that control group (5.1‰±12.6‰). Of these patients 122 patients were evaluated by endoscopic biopsy methods. Based on invasive tests, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of (13)C-UBT for the citric acid group were 83.3%, 91.7%, 81.3%, 55.0%, and 97.5%, respectively. Those of the control group were 87.7%, 90.9%, 88.2%, 62.5%, and 97.8%, respectively. They were not significantly different between the two groups. Although the presence of gastric atrophy and intestinal metaplasia (IM) decreased the accuracy, the decrease was not significant. CONCLUSIONS: In a country with high prevalence of atrophic gastritis or IM, false positivity remained common despite the use of citric acid in (13)C-UBT. Editorial Office of Gut and Liver 2019-09 2019-04-17 /pmc/articles/PMC6743802/ /pubmed/30970440 http://dx.doi.org/10.5009/gnl18398 Text en Copyright © 2019 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kwon, Yong Hwan
Kim, Nayoung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title_full Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title_fullStr Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title_full_unstemmed Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title_short Effect of Citric Acid on Accuracy of (13)C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis
title_sort effect of citric acid on accuracy of (13)c-urea breath test after helicobacter pylori eradication therapy in a region with a high prevalence of atrophic gastritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743802/
https://www.ncbi.nlm.nih.gov/pubmed/30970440
http://dx.doi.org/10.5009/gnl18398
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