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Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it oc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744224/ https://www.ncbi.nlm.nih.gov/pubmed/31453803 http://dx.doi.org/10.7554/eLife.46675 |
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author | Sánchez-Guardado, Luis Lois, Carlos |
author_facet | Sánchez-Guardado, Luis Lois, Carlos |
author_sort | Sánchez-Guardado, Luis |
collection | PubMed |
description | Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons. |
format | Online Article Text |
id | pubmed-6744224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67442242019-09-16 Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb Sánchez-Guardado, Luis Lois, Carlos eLife Developmental Biology Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons. eLife Sciences Publications, Ltd 2019-08-27 /pmc/articles/PMC6744224/ /pubmed/31453803 http://dx.doi.org/10.7554/eLife.46675 Text en © 2019, Sánchez-Guardado and Lois http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Sánchez-Guardado, Luis Lois, Carlos Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title | Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title_full | Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title_fullStr | Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title_full_unstemmed | Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title_short | Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
title_sort | lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744224/ https://www.ncbi.nlm.nih.gov/pubmed/31453803 http://dx.doi.org/10.7554/eLife.46675 |
work_keys_str_mv | AT sanchezguardadoluis lineagedoesnotregulatethesensorysynapticinputofprojectionneuronsinthemouseolfactorybulb AT loiscarlos lineagedoesnotregulatethesensorysynapticinputofprojectionneuronsinthemouseolfactorybulb |