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In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model
Colorectal cancer is the third leading cause of cancer death worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapies for treatment of solid tumours, including colorectal cancer. The efficacy of treatment is dependent on tumour type and can only be determined six weeks after...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744414/ https://www.ncbi.nlm.nih.gov/pubmed/31519979 http://dx.doi.org/10.1038/s41598-019-49716-7 |
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author | Shepelytskyi, Yurii Fox, Matthew S. Davenport, Karen Li, Tao Albert, Mitchell S. Davenport, Eric |
author_facet | Shepelytskyi, Yurii Fox, Matthew S. Davenport, Karen Li, Tao Albert, Mitchell S. Davenport, Eric |
author_sort | Shepelytskyi, Yurii |
collection | PubMed |
description | Colorectal cancer is the third leading cause of cancer death worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapies for treatment of solid tumours, including colorectal cancer. The efficacy of treatment is dependent on tumour type and can only be determined six weeks after beginning chemotherapy, with only 40–50% of patients responding positively to the 5-FU therapy. In this paper, we demonstrate the potential of using Magnetic Resonance (MR) Chemical Shift Imaging (CSI) for in-vivo monitoring of 5-FU tumor-retention in two different colorectal tumour types (HT-29 & H-508). Time curves for 5-FU signals from the liver and bladder were also acquired. We observed significant differences (p < 0.01) in 5-FU signal time dependencies for the HT-29 and H-508 tumours. Retention of 5-FU occurred in the H-508 tumour, whereas the HT-29 tumour is not expected to retain 5FU due to the observation of the negative b time constant indicating a decline in 5FU within the tumour. This study successfully demonstrates that CSI may be a useful tool for early identification of 5-FU responsive tumours based on observed tumour retention of the 5-FU. |
format | Online Article Text |
id | pubmed-6744414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67444142019-09-27 In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model Shepelytskyi, Yurii Fox, Matthew S. Davenport, Karen Li, Tao Albert, Mitchell S. Davenport, Eric Sci Rep Article Colorectal cancer is the third leading cause of cancer death worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapies for treatment of solid tumours, including colorectal cancer. The efficacy of treatment is dependent on tumour type and can only be determined six weeks after beginning chemotherapy, with only 40–50% of patients responding positively to the 5-FU therapy. In this paper, we demonstrate the potential of using Magnetic Resonance (MR) Chemical Shift Imaging (CSI) for in-vivo monitoring of 5-FU tumor-retention in two different colorectal tumour types (HT-29 & H-508). Time curves for 5-FU signals from the liver and bladder were also acquired. We observed significant differences (p < 0.01) in 5-FU signal time dependencies for the HT-29 and H-508 tumours. Retention of 5-FU occurred in the H-508 tumour, whereas the HT-29 tumour is not expected to retain 5FU due to the observation of the negative b time constant indicating a decline in 5FU within the tumour. This study successfully demonstrates that CSI may be a useful tool for early identification of 5-FU responsive tumours based on observed tumour retention of the 5-FU. Nature Publishing Group UK 2019-09-13 /pmc/articles/PMC6744414/ /pubmed/31519979 http://dx.doi.org/10.1038/s41598-019-49716-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shepelytskyi, Yurii Fox, Matthew S. Davenport, Karen Li, Tao Albert, Mitchell S. Davenport, Eric In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title | In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title_full | In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title_fullStr | In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title_full_unstemmed | In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title_short | In-Vivo Retention of 5-Fluorouracil Using (19)F Magnetic Resonance Chemical Shift Imaging in Colorectal Cancer in a Murine Model |
title_sort | in-vivo retention of 5-fluorouracil using (19)f magnetic resonance chemical shift imaging in colorectal cancer in a murine model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744414/ https://www.ncbi.nlm.nih.gov/pubmed/31519979 http://dx.doi.org/10.1038/s41598-019-49716-7 |
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