A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins

Pregnancy-associated plasma protein-A (PAPP-A) is a key regulator of insulin-like growth factor (IGF) bioactivity, by releasing the IGFs from their corresponding IGF-binding proteins (IGFBPs). The minor allele of the single nucleotide polymorphism (SNP), rs7020782 (serine < tyrosine), in PAPPA ha...

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Detalles Bibliográficos
Autores principales: Bøtkjær, Jane Alrø, Noer, Pernille Rimmer, Oxvig, Claus, Yding Andersen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744435/
https://www.ncbi.nlm.nih.gov/pubmed/31519945
http://dx.doi.org/10.1038/s41598-019-49626-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744435/
https://www.ncbi.nlm.nih.gov/pubmed/31519945
http://dx.doi.org/10.1038/s41598-019-49626-8

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