Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured muscle cells. However, its impact on muscle physiology and function in vivo is still unclear. Here, we show that muscle-specific HuR knockout (muHuR-KO) mice have high exercise endurance that is associated with...

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Detalles Bibliográficos
Autores principales: Janice Sánchez, Brenda, Tremblay, Anne-Marie K., Leduc-Gaudet, Jean-Philippe, Hall, Derek T., Kovacs, Erzsebet, Ma, Jennifer F., Mubaid, Souad, Hallauer, Patricia L., Phillips, Brittany L., Vest, Katherine E., Corbett, Anita H., Kontoyiannis, Dimitris L., Hussain, Sabah N. A., Hastings, Kenneth E. M., Di Marco, Sergio, Gallouzi, Imed-Eddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744452/
https://www.ncbi.nlm.nih.gov/pubmed/31519904
http://dx.doi.org/10.1038/s41467-019-12186-6

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