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The mutational landscape of a prion-like domain

Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause cellular toxicity is still not clear, even in simpler cellular systems. We reasoned...

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Detalles Bibliográficos
Autores principales:	Bolognesi, Benedetta, Faure, Andre J., Seuma, Mireia, Schmiedel, Jörn M., Tartaglia, Gian Gaetano, Lehner, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744496/ https://www.ncbi.nlm.nih.gov/pubmed/31519910 http://dx.doi.org/10.1038/s41467-019-12101-z

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