Obesity and the Risk of Gastrointestinal Cancers

Obesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointe...

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Autores principales: Karczewski, Jacek, Begier-Krasińska, Beata, Staszewski, Rafał, Popławska, Edyta, Gulczynska-Elhadi, Katarzyna, Dobrowolska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744518/
https://www.ncbi.nlm.nih.gov/pubmed/30968228
http://dx.doi.org/10.1007/s10620-019-05603-9
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author Karczewski, Jacek
Begier-Krasińska, Beata
Staszewski, Rafał
Popławska, Edyta
Gulczynska-Elhadi, Katarzyna
Dobrowolska, Agnieszka
author_facet Karczewski, Jacek
Begier-Krasińska, Beata
Staszewski, Rafał
Popławska, Edyta
Gulczynska-Elhadi, Katarzyna
Dobrowolska, Agnieszka
author_sort Karczewski, Jacek
collection PubMed
description Obesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointestinal cancer risk are being considered, including altered insulin signaling, obesity-associated chronic low-grade inflammation, and altered sex hormone metabolism, although new potential mechanisms emerge. This review is aimed to present our current knowledge on biological mechanisms involved in adiposity-related gastrointestinal carcinogenesis supported by results collected in epidemiological studies.
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spelling pubmed-67445182019-09-27 Obesity and the Risk of Gastrointestinal Cancers Karczewski, Jacek Begier-Krasińska, Beata Staszewski, Rafał Popławska, Edyta Gulczynska-Elhadi, Katarzyna Dobrowolska, Agnieszka Dig Dis Sci Review Obesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointestinal cancer risk are being considered, including altered insulin signaling, obesity-associated chronic low-grade inflammation, and altered sex hormone metabolism, although new potential mechanisms emerge. This review is aimed to present our current knowledge on biological mechanisms involved in adiposity-related gastrointestinal carcinogenesis supported by results collected in epidemiological studies. Springer US 2019-04-09 2019 /pmc/articles/PMC6744518/ /pubmed/30968228 http://dx.doi.org/10.1007/s10620-019-05603-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Karczewski, Jacek
Begier-Krasińska, Beata
Staszewski, Rafał
Popławska, Edyta
Gulczynska-Elhadi, Katarzyna
Dobrowolska, Agnieszka
Obesity and the Risk of Gastrointestinal Cancers
title Obesity and the Risk of Gastrointestinal Cancers
title_full Obesity and the Risk of Gastrointestinal Cancers
title_fullStr Obesity and the Risk of Gastrointestinal Cancers
title_full_unstemmed Obesity and the Risk of Gastrointestinal Cancers
title_short Obesity and the Risk of Gastrointestinal Cancers
title_sort obesity and the risk of gastrointestinal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744518/
https://www.ncbi.nlm.nih.gov/pubmed/30968228
http://dx.doi.org/10.1007/s10620-019-05603-9
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