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Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
BACKGROUND: Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer agents. Previous work revealed that cells from murine osteosarcomas were effic...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744692/ https://www.ncbi.nlm.nih.gov/pubmed/31521127 http://dx.doi.org/10.1186/s12885-019-6103-5 |