Cargando…

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

Hypervirulent Klebsiella pneumoniae (hvKp) is globally disseminating as a community-acquired pathogen causing life-threatening infections in healthy individuals. The fact that a dose as little as 50 bacteria is lethal to mice illustrates the dramatic increase of virulence associated with hvKp strain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feldman, Mario F., Mayer Bridwell, Anne E., Scott, Nichollas E., Vinogradov, Evgeny, McKee, Samuel R., Chavez, Sthefany M., Twentyman, Joy, Stallings, Christina L., Rosen, David A., Harding, Christian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744904/ https://www.ncbi.nlm.nih.gov/pubmed/31455739 http://dx.doi.org/10.1073/pnas.1907833116

Ejemplares similares

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities
por: Unterhauser, Katrin, et al.
Publicado: (2019)

Evolution of vertical and oblique transmission under fluctuating selection
por: Ram, Yoav, et al.
Publicado: (2018)

Evolution of resilience in protein interactomes across the tree of life
por: Zitnik, Marinka, et al.
Publicado: (2019)

Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program
por: Putney, Joy, et al.
Publicado: (2019)

Reactive school closure weakens the network of social interactions and reduces the spread of influenza
por: Litvinova, Maria, et al.
Publicado: (2019)

How a well-adapting immune system remembers
por: Mayer, Andreas, et al.
Publicado: (2019)

Stimulus generalization as a mechanism for learning to trust
por: FeldmanHall, Oriel, et al.
Publicado: (2018)

Predicting microbial growth in a mixed culture from growth curve data
por: Ram, Yoav, et al.
Publicado: (2019)

Metaproteomics method to determine carbon sources and assimilation pathways of species in microbial communities
por: Kleiner, Manuel, et al.
Publicado: (2018)

The evolution and genomic basis of beetle diversity
por: McKenna, Duane D., et al.
Publicado: (2019)

Paf1C regulates RNA polymerase II progression by modulating elongation rate
por: Hou, Liming, et al.
Publicado: (2019)

Structural basis of human kinesin-8 function and inhibition
por: Locke, Julia, et al.
Publicado: (2017)

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
por: Harding, Christian M., et al.
Publicado: (2019)

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
por: Thomas, Lance R., et al.
Publicado: (2019)

Daisy-chain gene drives for the alteration of local populations
por: Noble, Charleston, et al.
Publicado: (2019)

Near doubling of Brazil’s intensive row crop area since 2000
por: Zalles, Viviana, et al.
Publicado: (2019)

Phylogenetic approach to recover integration dates of latent HIV sequences within-host
por: Jones, Bradley R., et al.
Publicado: (2018)

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
por: Krendl, Christian, et al.
Publicado: (2017)

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption
por: Lu, Ching-Lan, et al.
Publicado: (2018)

Ancient trash mounds unravel urban collapse a century before the end of Byzantine hegemony in the southern Levant
por: Bar-Oz, Guy, et al.
Publicado: (2019)

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma
por: Hutter, Gregor, et al.
Publicado: (2019)

Drought delays development of the sorghum root microbiome and enriches for monoderm bacteria
por: Xu, Ling, et al.
Publicado: (2018)

Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses
por: Varoquaux, Nelle, et al.
Publicado: (2019)

Drugging an undruggable pocket on KRAS
por: Kessler, Dirk, et al.
Publicado: (2019)

Microbial communities in the tropical air ecosystem follow a precise diel cycle
por: Gusareva, Elena S., et al.
Publicado: (2019)

Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae
por: Wantuch, Paeton L., et al.
Publicado: (2023)

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
por: Spurny, Radovan, et al.
Publicado: (2015)

Metabolic and trophic interactions modulate methane production by Arctic peat microbiota in response to warming
por: Tveit, Alexander Tøsdal, et al.
Publicado: (2015)

Regulation of age-related macular degeneration-like pathology by complement factor H
por: Toomey, Christopher B., et al.
Publicado: (2015)

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
por: Babapoor-Farrokhran, Savalan, et al.
Publicado: (2015)

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met
por: Mizui, Toshiyuki, et al.
Publicado: (2015)

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy
por: Barrett, Christian L., et al.
Publicado: (2015)

Reduced endogenous Ca(2+) buffering speeds active zone Ca(2+) signaling
por: Delvendahl, Igor, et al.
Publicado: (2015)

Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish
por: Lisse, Thomas S., et al.
Publicado: (2016)

Analysis of high-resolution 3D intrachromosomal interactions aided by Bayesian network modeling
por: Zhang, Xizhe, et al.
Publicado: (2017)

Sparsity enables estimation of both subcortical and cortical activity from MEG and EEG
por: Krishnaswamy, Pavitra, et al.
Publicado: (2017)

Social preferences of future physicians
por: Li, Jing, et al.
Publicado: (2017)

Nutritional and greenhouse gas impacts of removing animals from US agriculture
por: White, Robin R., et al.
Publicado: (2017)

Proteome-wide modulation of degradation dynamics in response to growth arrest
por: Zhang, Tian, et al.
Publicado: (2017)

RNA stem structure governs coupling of dicing and gene silencing in RNA interference
por: Koh, Hye Ran, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vj9oki5c4pof76hhqgs4mopuen