Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

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Detalles Bibliográficos
Autores principales: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://www.ncbi.nlm.nih.gov/pubmed/31451672
http://dx.doi.org/10.1073/pnas.1908755116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://www.ncbi.nlm.nih.gov/pubmed/31451672
http://dx.doi.org/10.1073/pnas.1908755116

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