Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

A series of nine tetrahydroacridine derivatives with iodobenzoic moiety were synthesized and evaluated for their cytotoxic activity against cancer cell lines—A549 (human lung adenocarcinoma), HT-29 (human colorectal adenocarcinoma) and somatic cell line—EA.hy926 (human umbilical vein cell line). All...

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Detalles Bibliográficos
Autores principales: Girek, Małgorzata, Kłosiński, Karol, Grobelski, Bartłomiej, Pizzimenti, Stefania, Cucci, Marie Angele, Daga, Martina, Barrera, Giuseppina, Pasieka, Zbigniew, Czarnecka, Kamila, Szymański, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745035/
https://www.ncbi.nlm.nih.gov/pubmed/31313023
http://dx.doi.org/10.1007/s11010-019-03576-x

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