Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study

BACKGROUND: Germline DNA damage repair gene mutation (gDDRm) is found in >10% of metastatic prostate cancer (mPC). Their prognostic and predictive impact relating to standard therapies is unclear. OBJECTIVE: To determine whether gDDRm status impacts benefit from established therapies in mPC. DESI...

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Detalles Bibliográficos
Autores principales: Mateo, Joaquin, Cheng, Heather H., Beltran, Himisha, Dolling, David, Xu, Wen, Pritchard, Colin C., Mossop, Helen, Rescigno, Pasquale, Perez-Lopez, Raquel, Sailer, Verena, Kolinsky, Michael, Balasopoulou, Ada, Bertan, Claudia, Nanus, David M., Tagawa, Scott T., Thorne, Heather, Montgomery, Bruce, Carreira, Suzanne, Sandhu, Shahneen, Rubin, Mark A., Nelson, Peter S., de Bono, Johann S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745088/
https://www.ncbi.nlm.nih.gov/pubmed/29429804
http://dx.doi.org/10.1016/j.eururo.2018.01.010

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