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Role of Inflammatory Cell Subtypes in Heart Failure

Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Various types of immune cells are implicated in myoc...

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Autores principales: Strassheim, Derek, Dempsey, Edward C., Gerasimovskaya, Evgenia, Stenmark, Kurt, Karoor, Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745095/
https://www.ncbi.nlm.nih.gov/pubmed/31565659
http://dx.doi.org/10.1155/2019/2164017
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author Strassheim, Derek
Dempsey, Edward C.
Gerasimovskaya, Evgenia
Stenmark, Kurt
Karoor, Vijaya
author_facet Strassheim, Derek
Dempsey, Edward C.
Gerasimovskaya, Evgenia
Stenmark, Kurt
Karoor, Vijaya
author_sort Strassheim, Derek
collection PubMed
description Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. A better understanding of the temporal course of the infiltration of the different immune cells and their contribution to the inflammatory process may improve the success for therapy. This brief review outlines the major cell types involved in heart failure, and some of their actions are summarized in the supplementary figure.
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spelling pubmed-67450952019-09-29 Role of Inflammatory Cell Subtypes in Heart Failure Strassheim, Derek Dempsey, Edward C. Gerasimovskaya, Evgenia Stenmark, Kurt Karoor, Vijaya J Immunol Res Review Article Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. A better understanding of the temporal course of the infiltration of the different immune cells and their contribution to the inflammatory process may improve the success for therapy. This brief review outlines the major cell types involved in heart failure, and some of their actions are summarized in the supplementary figure. Hindawi 2019-09-02 /pmc/articles/PMC6745095/ /pubmed/31565659 http://dx.doi.org/10.1155/2019/2164017 Text en Copyright © 2019 Derek Strassheim et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Strassheim, Derek
Dempsey, Edward C.
Gerasimovskaya, Evgenia
Stenmark, Kurt
Karoor, Vijaya
Role of Inflammatory Cell Subtypes in Heart Failure
title Role of Inflammatory Cell Subtypes in Heart Failure
title_full Role of Inflammatory Cell Subtypes in Heart Failure
title_fullStr Role of Inflammatory Cell Subtypes in Heart Failure
title_full_unstemmed Role of Inflammatory Cell Subtypes in Heart Failure
title_short Role of Inflammatory Cell Subtypes in Heart Failure
title_sort role of inflammatory cell subtypes in heart failure
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745095/
https://www.ncbi.nlm.nih.gov/pubmed/31565659
http://dx.doi.org/10.1155/2019/2164017
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