Cargando…
CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas
BACKGROUND: Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 is as a hematopoietic growth factor that modulates proliferation, differentiation, and survival of macrophages. Moreover, CSF-1 has also been reported to be aberrantly expressed in several human can...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745102/ https://www.ncbi.nlm.nih.gov/pubmed/31565097 http://dx.doi.org/10.1155/2019/2724948 |
_version_ | 1783451485410951168 |
---|---|
author | Hsu, Wei-Chi Lee, Yi-Chen Liang, Peir-In Chang, Lin-Li Huang, A-Mei Lin, Hui-Hui Wu, Wen-Jeng Li, Ching-Chia Li, Wei-Ming Jhan, Jhen-Hao Ke, Hung-Lung |
author_facet | Hsu, Wei-Chi Lee, Yi-Chen Liang, Peir-In Chang, Lin-Li Huang, A-Mei Lin, Hui-Hui Wu, Wen-Jeng Li, Ching-Chia Li, Wei-Ming Jhan, Jhen-Hao Ke, Hung-Lung |
author_sort | Hsu, Wei-Chi |
collection | PubMed |
description | BACKGROUND: Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 is as a hematopoietic growth factor that modulates proliferation, differentiation, and survival of macrophages. Moreover, CSF-1 has also been reported to be aberrantly expressed in several human cancers. However, the precise role of CSF-1 in upper tract urothelial carcinomas (UTUC) has not been studied. In this research, we examined the clinical significance of CSF-1 expression in UTUC. MATERIALS AND METHODS: One hundred twelve cancer tissue samples of UTUC from patients were included in this study, and the other cohort of 35 UTUC were paired cancer-adjacent normal samples. CSF-1 expression was evaluated by immunohistochemistry, and the association of CSF-1 expression with different clinicopathological variables was analyzed. RESULTS: CSF-1 expression was higher in UTUC than in the normal urothelium (P = 0.005). The CSF-1 expression was primarily localized in the nucleus and was significantly correlated with tumor size (P = 0.04) and patients who had a high stage (P < 0.001), distant metastasis (P = 0.006), recurrence (P = 0.003), and cancer death (P = 0.005). High CSF-1 expression was correlated with poor disease-free survival (P = 0.008) and cancer-specific survival (P = 0.001). Our results also used univariate and multivariable analyses, which found that high CSF-1 expression was an independent predictor of poor disease-free survival (hazard ratio = 2.56; P = 0.007) and cancer-specific survival (hazard ratio = 5.14; P = 0.022). CONCLUSIONS: Our findings indicate that the expression of CSF-1 is a potential prognostic marker for predicting patient survival and recurrence in UTUC. |
format | Online Article Text |
id | pubmed-6745102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-67451022019-09-29 CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas Hsu, Wei-Chi Lee, Yi-Chen Liang, Peir-In Chang, Lin-Li Huang, A-Mei Lin, Hui-Hui Wu, Wen-Jeng Li, Ching-Chia Li, Wei-Ming Jhan, Jhen-Hao Ke, Hung-Lung Dis Markers Research Article BACKGROUND: Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 is as a hematopoietic growth factor that modulates proliferation, differentiation, and survival of macrophages. Moreover, CSF-1 has also been reported to be aberrantly expressed in several human cancers. However, the precise role of CSF-1 in upper tract urothelial carcinomas (UTUC) has not been studied. In this research, we examined the clinical significance of CSF-1 expression in UTUC. MATERIALS AND METHODS: One hundred twelve cancer tissue samples of UTUC from patients were included in this study, and the other cohort of 35 UTUC were paired cancer-adjacent normal samples. CSF-1 expression was evaluated by immunohistochemistry, and the association of CSF-1 expression with different clinicopathological variables was analyzed. RESULTS: CSF-1 expression was higher in UTUC than in the normal urothelium (P = 0.005). The CSF-1 expression was primarily localized in the nucleus and was significantly correlated with tumor size (P = 0.04) and patients who had a high stage (P < 0.001), distant metastasis (P = 0.006), recurrence (P = 0.003), and cancer death (P = 0.005). High CSF-1 expression was correlated with poor disease-free survival (P = 0.008) and cancer-specific survival (P = 0.001). Our results also used univariate and multivariable analyses, which found that high CSF-1 expression was an independent predictor of poor disease-free survival (hazard ratio = 2.56; P = 0.007) and cancer-specific survival (hazard ratio = 5.14; P = 0.022). CONCLUSIONS: Our findings indicate that the expression of CSF-1 is a potential prognostic marker for predicting patient survival and recurrence in UTUC. Hindawi 2019-08-21 /pmc/articles/PMC6745102/ /pubmed/31565097 http://dx.doi.org/10.1155/2019/2724948 Text en Copyright © 2019 Wei-Chi Hsu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hsu, Wei-Chi Lee, Yi-Chen Liang, Peir-In Chang, Lin-Li Huang, A-Mei Lin, Hui-Hui Wu, Wen-Jeng Li, Ching-Chia Li, Wei-Ming Jhan, Jhen-Hao Ke, Hung-Lung CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title | CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title_full | CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title_fullStr | CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title_full_unstemmed | CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title_short | CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas |
title_sort | csf-1 overexpression predicts poor prognosis in upper tract urothelial carcinomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745102/ https://www.ncbi.nlm.nih.gov/pubmed/31565097 http://dx.doi.org/10.1155/2019/2724948 |
work_keys_str_mv | AT hsuweichi csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT leeyichen csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT liangpeirin csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT changlinli csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT huangamei csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT linhuihui csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT wuwenjeng csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT lichingchia csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT liweiming csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT jhanjhenhao csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas AT kehunglung csf1overexpressionpredictspoorprognosisinuppertracturothelialcarcinomas |