Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their me...

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Detalles Bibliográficos
Autores principales: Katagiri, Katsunori, Shiga, Kiyoto, Saito, Daisuke, Oikawa, Shin‐ichi, Ikeda, Aya, Tsuchida, Kodai, Miyaguchi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745446/
https://www.ncbi.nlm.nih.gov/pubmed/31534732
http://dx.doi.org/10.1002/ccr3.2349
Descripción
Sumario:Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.

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