Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their me...

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Autores principales: Katagiri, Katsunori, Shiga, Kiyoto, Saito, Daisuke, Oikawa, Shin‐ichi, Ikeda, Aya, Tsuchida, Kodai, Miyaguchi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745446/
https://www.ncbi.nlm.nih.gov/pubmed/31534732
http://dx.doi.org/10.1002/ccr3.2349
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author Katagiri, Katsunori
Shiga, Kiyoto
Saito, Daisuke
Oikawa, Shin‐ichi
Ikeda, Aya
Tsuchida, Kodai
Miyaguchi, Jun
author_facet Katagiri, Katsunori
Shiga, Kiyoto
Saito, Daisuke
Oikawa, Shin‐ichi
Ikeda, Aya
Tsuchida, Kodai
Miyaguchi, Jun
author_sort Katagiri, Katsunori
collection PubMed
description Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.
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spelling pubmed-67454462019-09-18 Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma Katagiri, Katsunori Shiga, Kiyoto Saito, Daisuke Oikawa, Shin‐ichi Ikeda, Aya Tsuchida, Kodai Miyaguchi, Jun Clin Case Rep Case Reports Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months. John Wiley and Sons Inc. 2019-07-31 /pmc/articles/PMC6745446/ /pubmed/31534732 http://dx.doi.org/10.1002/ccr3.2349 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Katagiri, Katsunori
Shiga, Kiyoto
Saito, Daisuke
Oikawa, Shin‐ichi
Ikeda, Aya
Tsuchida, Kodai
Miyaguchi, Jun
Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_full Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_fullStr Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_full_unstemmed Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_short Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
title_sort amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745446/
https://www.ncbi.nlm.nih.gov/pubmed/31534732
http://dx.doi.org/10.1002/ccr3.2349
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