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Glutamine antagonism attenuates physical and cognitive deficits in a model of MS

OBJECTIVE: To measure the impact of JHU-083, a novel prodrug of the glutamine antagonist 6-diazo-5-oxo-l-norleucine, on immune cell proliferation and activation, along with physical and cognitive impairments associated with the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. METHO...

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Detalles Bibliográficos
Autores principales:	Hollinger, Kristen R., Smith, Matthew D., Kirby, Leslie A., Prchalova, Eva, Alt, Jesse, Rais, Rana, Calabresi, Peter A., Slusher, Barbara S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745721/ https://www.ncbi.nlm.nih.gov/pubmed/31467038 http://dx.doi.org/10.1212/NXI.0000000000000609

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