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Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction
Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles. Medical imaging is the cornerstone for response assessme...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745848/ https://www.ncbi.nlm.nih.gov/pubmed/31385454 http://dx.doi.org/10.1002/cam4.2464 |
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author | Wei, Hong Jiang, Hanyu Song, Bin |
author_facet | Wei, Hong Jiang, Hanyu Song, Bin |
author_sort | Wei, Hong |
collection | PubMed |
description | Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles. Medical imaging is the cornerstone for response assessment to immunotherapy and plays a critical role in monitoring of immune‐related adverse events (irAEs). Imaging‐based biomarkers have shown tremendous potential for the prediction of therapeutic efficacies and clinical outcomes in patients treated with checkpoint inhibitors. In this article, the landscape of current response assessment systems for immunotherapy was reviewed with a special focus on the latest advances in the assessment of responses to ICB. Emerging imaging biomarkers were discussed along with the challenges regarding their clinical transformation. In addition, the biological mechanisms and clinical applications of ICB and irAEs were also within the scope of this review. |
format | Online Article Text |
id | pubmed-6745848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67458482019-09-18 Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction Wei, Hong Jiang, Hanyu Song, Bin Cancer Med Clinical Cancer Research Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles. Medical imaging is the cornerstone for response assessment to immunotherapy and plays a critical role in monitoring of immune‐related adverse events (irAEs). Imaging‐based biomarkers have shown tremendous potential for the prediction of therapeutic efficacies and clinical outcomes in patients treated with checkpoint inhibitors. In this article, the landscape of current response assessment systems for immunotherapy was reviewed with a special focus on the latest advances in the assessment of responses to ICB. Emerging imaging biomarkers were discussed along with the challenges regarding their clinical transformation. In addition, the biological mechanisms and clinical applications of ICB and irAEs were also within the scope of this review. John Wiley and Sons Inc. 2019-08-05 /pmc/articles/PMC6745848/ /pubmed/31385454 http://dx.doi.org/10.1002/cam4.2464 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Wei, Hong Jiang, Hanyu Song, Bin Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title | Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title_full | Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title_fullStr | Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title_full_unstemmed | Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title_short | Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction |
title_sort | role of medical imaging for immune checkpoint blockade therapy: from response assessment to prognosis prediction |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745848/ https://www.ncbi.nlm.nih.gov/pubmed/31385454 http://dx.doi.org/10.1002/cam4.2464 |
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