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Anemia in the Elderly
Anemia affects a substantial fraction of the elderly population, representing a public health problem that is predicted to further increase in coming years because of the demographic drive. Being typically mild, it is falsely perceived as a minor problem, particularly in the elderly with multimorbid...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745992/ https://www.ncbi.nlm.nih.gov/pubmed/31723768 http://dx.doi.org/10.1097/HS9.0000000000000040 |
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author | Girelli, Domenico Marchi, Giacomo Camaschella, Clara |
author_facet | Girelli, Domenico Marchi, Giacomo Camaschella, Clara |
author_sort | Girelli, Domenico |
collection | PubMed |
description | Anemia affects a substantial fraction of the elderly population, representing a public health problem that is predicted to further increase in coming years because of the demographic drive. Being typically mild, it is falsely perceived as a minor problem, particularly in the elderly with multimorbidity, so that it often remains unrecognized and untreated. Indeed, mounting evidence indicates that anemia in the elderly (AE) is independently associated with disability and other major negative outcomes, including mortality. AE is generally multifactorial, but initial studies suggested that etiology remains unexplained in near one-third of cases. This proportion is consistently declining due to recent advances highlighting the role of several conditions including clonal hematopoiesis, “inflammaging,” correctable androgen deficiency in men, and under-recognized iron deficiency. Starting from a real-world case vignette illustrating a paradigmatic example of anemia in an elderly patient with multimorbidity, we review the main clinical and pathophysiological aspect of AE, giving some practical insights into how to manage similar cases. |
format | Online Article Text |
id | pubmed-6745992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67459922019-11-13 Anemia in the Elderly Girelli, Domenico Marchi, Giacomo Camaschella, Clara Hemasphere Reviews Anemia affects a substantial fraction of the elderly population, representing a public health problem that is predicted to further increase in coming years because of the demographic drive. Being typically mild, it is falsely perceived as a minor problem, particularly in the elderly with multimorbidity, so that it often remains unrecognized and untreated. Indeed, mounting evidence indicates that anemia in the elderly (AE) is independently associated with disability and other major negative outcomes, including mortality. AE is generally multifactorial, but initial studies suggested that etiology remains unexplained in near one-third of cases. This proportion is consistently declining due to recent advances highlighting the role of several conditions including clonal hematopoiesis, “inflammaging,” correctable androgen deficiency in men, and under-recognized iron deficiency. Starting from a real-world case vignette illustrating a paradigmatic example of anemia in an elderly patient with multimorbidity, we review the main clinical and pathophysiological aspect of AE, giving some practical insights into how to manage similar cases. Wolters Kluwer Health 2018-04-17 /pmc/articles/PMC6745992/ /pubmed/31723768 http://dx.doi.org/10.1097/HS9.0000000000000040 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Reviews Girelli, Domenico Marchi, Giacomo Camaschella, Clara Anemia in the Elderly |
title | Anemia in the Elderly |
title_full | Anemia in the Elderly |
title_fullStr | Anemia in the Elderly |
title_full_unstemmed | Anemia in the Elderly |
title_short | Anemia in the Elderly |
title_sort | anemia in the elderly |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745992/ https://www.ncbi.nlm.nih.gov/pubmed/31723768 http://dx.doi.org/10.1097/HS9.0000000000000040 |
work_keys_str_mv | AT girellidomenico anemiaintheelderly AT marchigiacomo anemiaintheelderly AT camaschellaclara anemiaintheelderly |