Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

[Image: see text] Many small molecule inhibitors of the cMET receptor tyrosine kinase have been evaluated in clinical trials for the treatment of cancer and resistance-conferring mutations of cMET are beginning to be reported for a number of such compounds. There is now a need to understand specific...

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Detalles Bibliográficos
Autores principales: Collie, Gavin W., Koh, Cheryl M., O’Neill, Daniel J., Stubbs, Christopher J., Khurana, Puneet, Eddershaw, Alice, Snijder, Arjan, Mauritzson, Fredrik, Barlind, Louise, Dale, Ian L., Shaw, Joseph, Phillips, Christopher, Hennessy, Edward J., Cheung, Tony, Narvaez, Ana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746082/
https://www.ncbi.nlm.nih.gov/pubmed/31531204
http://dx.doi.org/10.1021/acsmedchemlett.9b00276

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