Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition with antiangiogenic activity, four novel series...

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Detalles Bibliográficos
Autores principales: Jaballah, Maiy Y., Serya, Rabah A. T., Saad, Nasser, Khojah, Sohair M., Ahmed, Marawan, Barakat, Khaled, Abouzid, Khaled A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746272/
https://www.ncbi.nlm.nih.gov/pubmed/31852269
http://dx.doi.org/10.1080/14756366.2019.1651723

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