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Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition

Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or ‘motor slowing’) to study the central component of fatigability in healthy adults. We show that motor slowin...

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Autores principales: Bächinger, Marc, Lehner, Rea, Thomas, Felix, Hanimann, Samira, Balsters, Joshua, Wenderoth, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746551/
https://www.ncbi.nlm.nih.gov/pubmed/31524600
http://dx.doi.org/10.7554/eLife.46750
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author Bächinger, Marc
Lehner, Rea
Thomas, Felix
Hanimann, Samira
Balsters, Joshua
Wenderoth, Nicole
author_facet Bächinger, Marc
Lehner, Rea
Thomas, Felix
Hanimann, Samira
Balsters, Joshua
Wenderoth, Nicole
author_sort Bächinger, Marc
collection PubMed
description Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or ‘motor slowing’) to study the central component of fatigability in healthy adults. We show that motor slowing is associated with a gradual increase of net excitability in the motor network and, specifically, in primary motor cortex (M1), which results from overall disinhibition. Importantly, we link performance decrements to a breakdown of surround inhibition in M1, which is associated with high coactivation of antagonistic muscle groups. This is consistent with the model that a loss of inhibitory control might broaden the tuning of population vectors such that movement patterns become more variable, ill-timed and effortful. We propose that the release of inhibition in M1 is an important mechanism underpinning motor fatigability and, potentially, also pathological fatigue as frequently observed in patients with brain disorders.
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spelling pubmed-67465512019-09-18 Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition Bächinger, Marc Lehner, Rea Thomas, Felix Hanimann, Samira Balsters, Joshua Wenderoth, Nicole eLife Neuroscience Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or ‘motor slowing’) to study the central component of fatigability in healthy adults. We show that motor slowing is associated with a gradual increase of net excitability in the motor network and, specifically, in primary motor cortex (M1), which results from overall disinhibition. Importantly, we link performance decrements to a breakdown of surround inhibition in M1, which is associated with high coactivation of antagonistic muscle groups. This is consistent with the model that a loss of inhibitory control might broaden the tuning of population vectors such that movement patterns become more variable, ill-timed and effortful. We propose that the release of inhibition in M1 is an important mechanism underpinning motor fatigability and, potentially, also pathological fatigue as frequently observed in patients with brain disorders. eLife Sciences Publications, Ltd 2019-09-16 /pmc/articles/PMC6746551/ /pubmed/31524600 http://dx.doi.org/10.7554/eLife.46750 Text en © 2019, Bächinger et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Bächinger, Marc
Lehner, Rea
Thomas, Felix
Hanimann, Samira
Balsters, Joshua
Wenderoth, Nicole
Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title_full Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title_fullStr Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title_full_unstemmed Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title_short Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
title_sort human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746551/
https://www.ncbi.nlm.nih.gov/pubmed/31524600
http://dx.doi.org/10.7554/eLife.46750
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