Cargando…

Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats

PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidne...

Descripción completa

Detalles Bibliográficos
Autores principales: Ke, Yixin, Yu, Kaihang, Zeng, Weiliang, Lian, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746561/
https://www.ncbi.nlm.nih.gov/pubmed/31531540
http://dx.doi.org/10.1590/s0102-865020190070000006
_version_ 1783451712186482688
author Ke, Yixin
Yu, Kaihang
Zeng, Weiliang
Lian, Guojun
author_facet Ke, Yixin
Yu, Kaihang
Zeng, Weiliang
Lian, Guojun
author_sort Ke, Yixin
collection PubMed
description PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl(2) group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl(2) treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl(2) treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl(2) treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl(2) treatment. CONCLUSION: PFE could protect the kidney against acute renal toxicity induced by CdCl(2).
format Online
Article
Text
id pubmed-6746561
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
record_format MEDLINE/PubMed
spelling pubmed-67465612019-09-25 Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats Ke, Yixin Yu, Kaihang Zeng, Weiliang Lian, Guojun Acta Cir Bras Original Article PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl(2) group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl(2) treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl(2) treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl(2) treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl(2) treatment. CONCLUSION: PFE could protect the kidney against acute renal toxicity induced by CdCl(2). Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-09-12 /pmc/articles/PMC6746561/ /pubmed/31531540 http://dx.doi.org/10.1590/s0102-865020190070000006 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ke, Yixin
Yu, Kaihang
Zeng, Weiliang
Lian, Guojun
Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title_full Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title_fullStr Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title_full_unstemmed Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title_short Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
title_sort protective roles of pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746561/
https://www.ncbi.nlm.nih.gov/pubmed/31531540
http://dx.doi.org/10.1590/s0102-865020190070000006
work_keys_str_mv AT keyixin protectiverolesofpyracanthafortuneanaextractonacuterenaltoxicityinducedbycadmiumchlorideinrats
AT yukaihang protectiverolesofpyracanthafortuneanaextractonacuterenaltoxicityinducedbycadmiumchlorideinrats
AT zengweiliang protectiverolesofpyracanthafortuneanaextractonacuterenaltoxicityinducedbycadmiumchlorideinrats
AT lianguojun protectiverolesofpyracanthafortuneanaextractonacuterenaltoxicityinducedbycadmiumchlorideinrats