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Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidne...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746561/ https://www.ncbi.nlm.nih.gov/pubmed/31531540 http://dx.doi.org/10.1590/s0102-865020190070000006 |
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author | Ke, Yixin Yu, Kaihang Zeng, Weiliang Lian, Guojun |
author_facet | Ke, Yixin Yu, Kaihang Zeng, Weiliang Lian, Guojun |
author_sort | Ke, Yixin |
collection | PubMed |
description | PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl(2) group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl(2) treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl(2) treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl(2) treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl(2) treatment. CONCLUSION: PFE could protect the kidney against acute renal toxicity induced by CdCl(2). |
format | Online Article Text |
id | pubmed-6746561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-67465612019-09-25 Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats Ke, Yixin Yu, Kaihang Zeng, Weiliang Lian, Guojun Acta Cir Bras Original Article PURPOSE: To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl(2)) in rats. METHODS: Rats were pretreated with PFE and consecutively injected with CdCl(2) (6.5 mg/kg) for 5 days. RESULTS: The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl(2) group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl(2) treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl(2) treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl(2) treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl(2) treatment. CONCLUSION: PFE could protect the kidney against acute renal toxicity induced by CdCl(2). Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-09-12 /pmc/articles/PMC6746561/ /pubmed/31531540 http://dx.doi.org/10.1590/s0102-865020190070000006 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ke, Yixin Yu, Kaihang Zeng, Weiliang Lian, Guojun Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats |
title | Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
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title_full | Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
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title_fullStr | Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
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title_full_unstemmed | Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
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title_short | Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
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title_sort | protective roles of pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746561/ https://www.ncbi.nlm.nih.gov/pubmed/31531540 http://dx.doi.org/10.1590/s0102-865020190070000006 |
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