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Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: contro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746564/ https://www.ncbi.nlm.nih.gov/pubmed/31531539 http://dx.doi.org/10.1590/s0102-865020190070000004 |
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author | Laçin, Nihat Deveci, Engin |
author_facet | Laçin, Nihat Deveci, Engin |
author_sort | Laçin, Nihat |
collection | PubMed |
description | PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. RESULTS: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. CONCLUSION: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment. |
format | Online Article Text |
id | pubmed-6746564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-67465642019-09-25 Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats Laçin, Nihat Deveci, Engin Acta Cir Bras Original Article PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. RESULTS: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. CONCLUSION: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-09-12 /pmc/articles/PMC6746564/ /pubmed/31531539 http://dx.doi.org/10.1590/s0102-865020190070000004 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Laçin, Nihat Deveci, Engin Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats |
title | Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
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title_full | Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
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title_fullStr | Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
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title_full_unstemmed | Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
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title_short | Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
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title_sort | short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746564/ https://www.ncbi.nlm.nih.gov/pubmed/31531539 http://dx.doi.org/10.1590/s0102-865020190070000004 |
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