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Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: contro...

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Autores principales: Laçin, Nihat, Deveci, Engin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746564/
https://www.ncbi.nlm.nih.gov/pubmed/31531539
http://dx.doi.org/10.1590/s0102-865020190070000004
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author Laçin, Nihat
Deveci, Engin
author_facet Laçin, Nihat
Deveci, Engin
author_sort Laçin, Nihat
collection PubMed
description PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. RESULTS: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. CONCLUSION: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment.
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spelling pubmed-67465642019-09-25 Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats Laçin, Nihat Deveci, Engin Acta Cir Bras Original Article PURPOSE: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. METHODS: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. RESULTS: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. CONCLUSION: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-09-12 /pmc/articles/PMC6746564/ /pubmed/31531539 http://dx.doi.org/10.1590/s0102-865020190070000004 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Laçin, Nihat
Deveci, Engin
Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title_full Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title_fullStr Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title_full_unstemmed Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title_short Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
title_sort short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746564/
https://www.ncbi.nlm.nih.gov/pubmed/31531539
http://dx.doi.org/10.1590/s0102-865020190070000004
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