Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature

A 62-year-old man presented to our hospital for the further evaluation and treatment of his back pain, general fatigue, and dyspnea, which had developed 4 days after the 29th administration of nivolumab to treat his lung cancer. Based on his clinical history, elevated serum cardiac enzyme values, an...

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Autores principales: Matsuo, Keisuke, Ishiguro, Takashi, Najama, Takatomo, Shimizu, Yoshihiko, Kobayashi, Yasuhito, Mutou, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746646/
https://www.ncbi.nlm.nih.gov/pubmed/31118387
http://dx.doi.org/10.2169/internalmedicine.2596-18
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author Matsuo, Keisuke
Ishiguro, Takashi
Najama, Takatomo
Shimizu, Yoshihiko
Kobayashi, Yasuhito
Mutou, Makoto
author_facet Matsuo, Keisuke
Ishiguro, Takashi
Najama, Takatomo
Shimizu, Yoshihiko
Kobayashi, Yasuhito
Mutou, Makoto
author_sort Matsuo, Keisuke
collection PubMed
description A 62-year-old man presented to our hospital for the further evaluation and treatment of his back pain, general fatigue, and dyspnea, which had developed 4 days after the 29th administration of nivolumab to treat his lung cancer. Based on his clinical history, elevated serum cardiac enzyme values, and cardiac magnetic resonance (CMR) imaging and myocardial biopsy findings, he was diagnosed with myocarditis induced by nivolumab. Corticosteroid therapy improved his condition, and CMR performed on hospital day 11 also showed remarkable improvement. Although nivolumab-induced myocarditis is rare, cardiologists should consider it when encountering patients treated with such a drug for malignant disease.
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spelling pubmed-67466462019-09-17 Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature Matsuo, Keisuke Ishiguro, Takashi Najama, Takatomo Shimizu, Yoshihiko Kobayashi, Yasuhito Mutou, Makoto Intern Med Case Report A 62-year-old man presented to our hospital for the further evaluation and treatment of his back pain, general fatigue, and dyspnea, which had developed 4 days after the 29th administration of nivolumab to treat his lung cancer. Based on his clinical history, elevated serum cardiac enzyme values, and cardiac magnetic resonance (CMR) imaging and myocardial biopsy findings, he was diagnosed with myocarditis induced by nivolumab. Corticosteroid therapy improved his condition, and CMR performed on hospital day 11 also showed remarkable improvement. Although nivolumab-induced myocarditis is rare, cardiologists should consider it when encountering patients treated with such a drug for malignant disease. The Japanese Society of Internal Medicine 2019-05-22 2019-08-15 /pmc/articles/PMC6746646/ /pubmed/31118387 http://dx.doi.org/10.2169/internalmedicine.2596-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsuo, Keisuke
Ishiguro, Takashi
Najama, Takatomo
Shimizu, Yoshihiko
Kobayashi, Yasuhito
Mutou, Makoto
Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title_full Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title_fullStr Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title_full_unstemmed Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title_short Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
title_sort nivolumab-induced myocarditis successfully treated with corticosteroid therapy: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746646/
https://www.ncbi.nlm.nih.gov/pubmed/31118387
http://dx.doi.org/10.2169/internalmedicine.2596-18
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