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Distinct effects of Q925 mutation on intracellular and extracellular Na(+) and K(+) binding to the Na(+), K(+)-ATPase

Three Na(+) sites are defined in the Na(+)-bound crystal structure of Na(+), K(+)-ATPase. Sites I and II overlap with two K(+) sites in the K(+)-bound structure, whereas site III is unique and Na(+) specific. A glutamine in transmembrane helix M8 (Q925) appears from the crystal structures to coordin...

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Detalles Bibliográficos
Autores principales:	Nielsen, Hang N., Spontarelli, Kerri, Holm, Rikke, Andersen, Jens Peter, Einholm, Anja P., Artigas, Pablo, Vilsen, Bente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746705/ https://www.ncbi.nlm.nih.gov/pubmed/31527711 http://dx.doi.org/10.1038/s41598-019-50009-2

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