Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25...

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Autores principales: An, Jiyuan, Gharahkhani, Puya, Law, Matthew H., Ong, Jue-Sheng, Han, Xikun, Olsen, Catherine M., Neale, Rachel E., Lai, John, Vaughan, Tom L., Gockel, Ines, Thieme, René, Böhmer, Anne C., Jankowski, Janusz, Fitzgerald, Rebecca C., Schumacher, Johannes, Palles, Claire, Whiteman, David C., MacGregor, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746768/
https://www.ncbi.nlm.nih.gov/pubmed/31527586
http://dx.doi.org/10.1038/s41467-019-11968-2
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author An, Jiyuan
Gharahkhani, Puya
Law, Matthew H.
Ong, Jue-Sheng
Han, Xikun
Olsen, Catherine M.
Neale, Rachel E.
Lai, John
Vaughan, Tom L.
Gockel, Ines
Thieme, René
Böhmer, Anne C.
Jankowski, Janusz
Fitzgerald, Rebecca C.
Schumacher, Johannes
Palles, Claire
Whiteman, David C.
MacGregor, Stuart
author_facet An, Jiyuan
Gharahkhani, Puya
Law, Matthew H.
Ong, Jue-Sheng
Han, Xikun
Olsen, Catherine M.
Neale, Rachel E.
Lai, John
Vaughan, Tom L.
Gockel, Ines
Thieme, René
Böhmer, Anne C.
Jankowski, Janusz
Fitzgerald, Rebecca C.
Schumacher, Johannes
Palles, Claire
Whiteman, David C.
MacGregor, Stuart
author_sort An, Jiyuan
collection PubMed
description Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions.
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spelling pubmed-67467682019-09-18 Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases An, Jiyuan Gharahkhani, Puya Law, Matthew H. Ong, Jue-Sheng Han, Xikun Olsen, Catherine M. Neale, Rachel E. Lai, John Vaughan, Tom L. Gockel, Ines Thieme, René Böhmer, Anne C. Jankowski, Janusz Fitzgerald, Rebecca C. Schumacher, Johannes Palles, Claire Whiteman, David C. MacGregor, Stuart Nat Commun Article Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions. Nature Publishing Group UK 2019-09-16 /pmc/articles/PMC6746768/ /pubmed/31527586 http://dx.doi.org/10.1038/s41467-019-11968-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
An, Jiyuan
Gharahkhani, Puya
Law, Matthew H.
Ong, Jue-Sheng
Han, Xikun
Olsen, Catherine M.
Neale, Rachel E.
Lai, John
Vaughan, Tom L.
Gockel, Ines
Thieme, René
Böhmer, Anne C.
Jankowski, Janusz
Fitzgerald, Rebecca C.
Schumacher, Johannes
Palles, Claire
Whiteman, David C.
MacGregor, Stuart
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title_full Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title_fullStr Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title_full_unstemmed Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title_short Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
title_sort gastroesophageal reflux gwas identifies risk loci that also associate with subsequent severe esophageal diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746768/
https://www.ncbi.nlm.nih.gov/pubmed/31527586
http://dx.doi.org/10.1038/s41467-019-11968-2
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