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An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor clinical prognosis and limited targeted treatment strategies. Kinase inhibitor screening of a panel of 20 TNBC cell lines uncovered three critical TNBC subgroups: 1) sensitive to only MEK inhibitors; 2) sensitiv...

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Detalles Bibliográficos
Autores principales:	van der Noord, Vera E., McLaughlin, Ronan P., Smid, Marcel, Foekens, John A., Martens, John W. M., Zhang, Yinghui, van de Water, Bob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746778/ https://www.ncbi.nlm.nih.gov/pubmed/31527768 http://dx.doi.org/10.1038/s41598-019-49809-3

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