Imaging of hepatic drug transporters with [(131)I]6-β-iodomethyl-19-norcholesterol

We examined whether [(131)I]6-β-iodomethyl-19-norcholesterol (NP-59), a cholesterol analog, can be used to measure function of hepatic drug transporters. Hepatic uptake of NP-59 with and without rifampicin was evaluated using HEK293 cells expressing solute carrier transporters. The stability of NP-5...

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Detalles Bibliográficos
Autores principales: Kobayashi, Masato, Nishi, Kodai, Mizutani, Asuka, Hokama, Tsuzumi, Matsue, Miki, Tsujikawa, Tetsuya, Nakanishi, Takeo, Nishii, Ryuichi, Tamai, Ikumi, Kawai, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746803/
https://www.ncbi.nlm.nih.gov/pubmed/31527775
http://dx.doi.org/10.1038/s41598-019-50049-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746803/
https://www.ncbi.nlm.nih.gov/pubmed/31527775
http://dx.doi.org/10.1038/s41598-019-50049-8

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