Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation

In this study, an untargeted metabolomics approach was used to assess the effects of proton irradiation (1 Gy of 150 MeV) on the metabolome and DNA methylation pattern in the murine hippocampus and left ventricle of the heart 22 weeks following exposure using an integrated metabolomics-DNA methylati...

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Detalles Bibliográficos
Autores principales: Torres, Eileen Ruth S., Hall, Reed, Bobe, Gerd, Choi, Jaewoo, Impey, Soren, Pelz, Carl, Lindner, Jonathan R., Stevens, Jan F., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746933/
https://www.ncbi.nlm.nih.gov/pubmed/31552266
http://dx.doi.org/10.3389/fmolb.2019.00077

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