A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells

The pro-apoptotic proteins BAX and BAK are critical regulatory factors constituting the apoptosis machinery. Downregulated expression of BAX and BAK in human colorectal cancer lead to chemotherapeutic failure and poor survival rate in patients. In this study, isogenic DLD-1 colon cancer cells and th...

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Detalles Bibliográficos
Autores principales: Han, Yu, Qu, Yuan Qing, Mok, Simon Wing Fai, Chen, Juan, Xia, Cheng Lai, He, Hu Qiang, Li, Zheng, Zhang, Wei, Qiu, Cong Ling, Liu, Liang, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746939/
https://www.ncbi.nlm.nih.gov/pubmed/31551763
http://dx.doi.org/10.3389/fphar.2019.00912

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