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In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of Association

Background: Association studies of epigenome-wide DNA methylation and disease can inform biological mechanisms. DNA methylation is often measured in peripheral blood, with heterogeneous cell types with different methylation profiles. Influences such as adiposity-associated inflammation can change ce...

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Detalles Bibliográficos
Autores principales:	Barton, Sheila J., Melton, Phillip E., Titcombe, Philip, Murray, Robert, Rauschert, Sebastian, Lillycrop, Karen A., Huang, Rae-Chi, Holbrook, Joanna D., Godfrey, Keith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746958/ https://www.ncbi.nlm.nih.gov/pubmed/31552104 http://dx.doi.org/10.3389/fgene.2019.00816

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