Cargando…

Metabolomics Analysis Reveals the Protection Mechanism of Huangqi–Danshen Decoction on Adenine-Induced Chronic Kidney Disease in Rats

Huangqi–Danshen decoction (HDD) is a commonly used drug pair for clinical treatment of chronic kidney disease (CKD) in traditional Chinese medicine with good efficacy. However, the potential mechanisms of this action have not been well elucidated. The aim of this study was to explore the metabolic p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xinhui, Zhang, Bing, Huang, Shiying, Wang, Fochang, Zheng, Lin, Lu, Jiandong, Zeng, Youjia, Chen, Jianping, Li, Shunmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747014/ https://www.ncbi.nlm.nih.gov/pubmed/31551789 http://dx.doi.org/10.3389/fphar.2019.00992

Ejemplares similares

Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics
por: Liu, Xinhui, et al.
Publicado: (2019)

Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice
por: Liu, Xinhui, et al.
Publicado: (2023)

Involvement of Circulating Exosomal MicroRNAs in Jian-Pi-Yi-Shen Formula Protection Against Adenine-Induced Chronic Kidney Disease
por: Liu, Xinhui, et al.
Publicado: (2021)

Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease
por: Liu, Xinhui, et al.
Publicado: (2021)

Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway
por: Wei, Xian, et al.
Publicado: (2022)

Lipidomics reveals the potential mechanism of honokiol against adenine-induced chronic kidney disease
por: Liu, Xinhui, et al.
Publicado: (2022)

Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling
por: Liu, Xinhui, et al.
Publicado: (2022)

Distinct Responses of Gut Microbiota to Jian-Pi-Yi-Shen Decoction Are Associated With Improved Clinical Outcomes in 5/6 Nephrectomized Rats
por: Zheng, Lin, et al.
Publicado: (2020)

Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin-Induced Acute Kidney Injury
por: Li, Yuyan, et al.
Publicado: (2020)

Biomarker identification and pathway analysis of Astragalus membranaceus and Curcuma zedoaria couplet medicines on adenine-induced chronic kidney disease in rats based on metabolomics
por: Lu, Lingfei, et al.
Publicado: (2023)

Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction
por: Pan, Boyu, et al.
Publicado: (2022)

Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition
por: Zhao, Yuan, et al.
Publicado: (2022)

Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD(+)/SIRT3/Mitochondrial Dynamics Pathway
por: Liu, Xinhui, et al.
Publicado: (2021)

Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 5/6 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling
por: Chen, Jianping, et al.
Publicado: (2019)

Microbiome-Metabolomics Analysis Reveals the Protection Mechanism of α-Ketoacid on Adenine-Induced Chronic Kidney Disease in Rats
por: Mo, Yenan, et al.
Publicado: (2021)

Huangqi Guizhi Wuwu Decoction Improves Arthritis and Pathological Damage of Heart and Lung in TNF-Tg Mice
por: Wang, Yi, et al.
Publicado: (2022)

Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice
por: Wu, Jia-Sheng, et al.
Publicado: (2017)

Meta-Analysis of the Clinical Value of Danshen Injection and Huangqi Injection in Liver Cirrhosis
por: Zhu, Changtai, et al.
Publicado: (2013)

Metabolomics Reveals Effect of Zishen Jiangtang Pill, a Chinese Herbal Product on High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice
por: Chen, Jianping, et al.
Publicado: (2019)

Modified Huangqi Chifeng Decoction Attenuates Proteinuria by Reducing Podocyte Injury in a Rat Model of Immunoglobulin a Nephropathy
por: Chang, Meiying, et al.
Publicado: (2021)

Pharmacological and molecular analysis of the effects of Huangqi Jianzhong decoction on proliferation and apoptosis in GES-1 cells infected with H. pylori
por: Hu, Jingnan, et al.
Publicado: (2022)

Uterine Metabolomics Reveals Protection of Taohong Siwu Decoction Against Abnormal Uterine Bleeding
por: Zhang, Yanyan, et al.
Publicado: (2020)

Effects of Huangqi Liuyi Decoction in the Treatment of Diabetic Nephropathy and Tissue Distribution Difference of its Six Active Constituents Between Normal and Diabetic Nephropathy Mouse Models
por: Wang, Qun, et al.
Publicado: (2022)

Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation
por: Biao, Yaning, et al.
Publicado: (2022)

Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke
por: Yang, Lingling, et al.
Publicado: (2022)

Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling
por: Wang, Fochang, et al.
Publicado: (2020)

Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis
por: Wang, Rui, et al.
Publicado: (2022)

Network Pharmacology Analysis of Huangqi Jianzhong Tang Targets in Gastric Cancer
por: Li, Long, et al.
Publicado: (2022)

Coadministration of Compound Danshen dripping pills and bezafibrate has a protective effect against diabetic retinopathy
por: Liu, Le, et al.
Publicado: (2022)

Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway
por: Chen, Ying, et al.
Publicado: (2023)

Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice
por: Chen, Wei, et al.
Publicado: (2023)

Screening for Potential Active Components of Fangji Huangqi Tang on the Treatment of Nephrotic Syndrome by Using Integrated Metabolomics Based on “Correlations Between Chemical and Metabolic Profiles”
por: Liu, Xiao, et al.
Publicado: (2019)

System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus
por: Yue, Shi-Jun, et al.
Publicado: (2017)

Mechanism of Huangqi Sanxian Decoction Inhibiting Osteoclast Differentiation Based on Network Pharmacology
por: Shi, Jian-Xin, et al.
Publicado: (2022)

An exploratory study on the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of neuropathic pain
por: Luo, Bo‐Yan, et al.
Publicado: (2022)

Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis
por: Zhang, Gui-biao, et al.
Publicado: (2015)

Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics
por: Yin, Fengxia, et al.
Publicado: (2022)

Danshen (Salvia miltiorrhiza) on the Global Market: What Are the Implications for Products’ Quality?
por: Kum, Ka Yui, et al.
Publicado: (2021)

Antiosteoporotic Effects of Huangqi Sanxian Decoction in Cultured Rat Osteoblasts by Proteomic Characterization of the Target and Mechanism
por: Guo, Chong-Chong, et al.
Publicado: (2015)

Chemical characterization and metabolic profiling of Xiao-Er-An-Shen Decoction by UPLC-QTOF/MS
por: Yang, Ruipei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kiminnd2da19qpfj3f1kkdkagk