Cargando…

Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Hyeanjeong, Shin, Seulgi, Lee, Jun-Seok, Lee, Soo Hyun, Baik, Ja-Hyun, Lim, Sungsu, Kim, Yun Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747090/ https://www.ncbi.nlm.nih.gov/pubmed/31480543 http://dx.doi.org/10.3390/ijms20174283

Ejemplares similares

Visualization of Tau–Tubulin Interaction in a Living Cell Using Bifluorescence Complementation Technique
por: Shin, Seulgi, et al.
Publicado: (2018)

Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in Tau(P301L)-BiFC mice
por: Lim, Sungsu, et al.
Publicado: (2023)

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors
por: Lim, Sungsu, et al.
Publicado: (2015)

Metal Ion Effects on Aβ and Tau Aggregation
por: Kim, Anne Claire, et al.
Publicado: (2018)

Cell-based Models To Investigate Tau Aggregation
por: Lim, Sungsu, et al.
Publicado: (2014)

The Fate of Tau Aggregates Between Clearance and Transmission
por: Seitkazina, Assel, et al.
Publicado: (2022)

Identification of disulfide cross-linked tau dimer responsible for tau propagation
por: Kim, Dohee, et al.
Publicado: (2015)

Structure-based inhibitors of tau aggregation
por: Seidler, PM, et al.
Publicado: (2017)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
por: Cook, Casey, et al.
Publicado: (2014)

Bimolecular Fluorescence Complementation; Lighting-Up Tau-Tau Interaction in Living Cells
por: Tak, HyeJin, et al.
Publicado: (2013)

Glioblastoma-secreted soluble CD44 activates tau pathology in the brain
por: Lim, Sungsu, et al.
Publicado: (2018)

Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
por: Shin, Soo Jung, et al.
Publicado: (2020)

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models
por: Choi, Heesun, et al.
Publicado: (2019)

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function
por: Carlomagno, Yari, et al.
Publicado: (2017)

Potential synergy between tau aggregation inhibitors and tau chaperone modulators
por: Blair, Laura J, et al.
Publicado: (2013)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation
por: Cohen, Todd J., et al.
Publicado: (2016)

Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

EGCG impedes human Tau aggregation and interacts with Tau
por: Sonawane, Shweta Kishor, et al.
Publicado: (2020)

PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
por: Soares, Alberto Carpinteiro, et al.
Publicado: (2021)

Acetylation of Tau Induces Alzheimer's Disease-Associated Tau in Transgenic Mice
por: Ali, Addison, et al.
Publicado: (2021)

Acetylation of Tau Induces Alzheimer's Disease-Associated Tau in Transgenic Mice
por: Ali, Addison, et al.
Publicado: (2021)

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model
por: Riedel, Gernot, et al.
Publicado: (2020)

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau
por: Takahashi, Muneaki, et al.
Publicado: (2015)

Acetylation Disfavors Tau Phase Separation
por: Ferreon, Josephine C., et al.
Publicado: (2018)

Toxic tau: structural origins of tau aggregation in Alzheimer's disease
por: Mamun, Abdullah Al, et al.
Publicado: (2020)

PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo
por: Okuda, Michiaki, et al.
Publicado: (2015)

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Caspase-Mediated Truncation of Tau Potentiates Aggregation
por: Lee, Sangmook, et al.
Publicado: (2012)

Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation
por: Luo, Yin, et al.
Publicado: (2014)

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
por: Caballero, Benjamin, et al.
Publicado: (2021)

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
por: Pickhardt, Marcus, et al.
Publicado: (2015)

Acetylation discriminates disease-specific tau deposition
por: Chakraborty, Pijush, et al.
Publicado: (2023)

Degradation or aggregation: the ramifications of post-translational modifications on tau
por: Park, Seoyoung, et al.
Publicado: (2018)

Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
por: Alquezar, Carolina, et al.
Publicado: (2021)

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
por: Ishida, Kazuhisa, et al.
Publicado: (2022)

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments
por: Kim, Ji Hyeon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sh63rfeb44v6dj58lo9ss65kfs