Physiologically Relevant Oxygen Concentration (6% O(2)) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

Cancer cell phenotype largely depends on oxygen availability. The atmospheric oxygen concentration (21%) used in in vitro studies is much higher than in any human tissue. Using well-characterized patient-derived melanoma cell lines, we compared: (i) activities of several signaling pathways, and (ii)...

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Detalles Bibliográficos
Autores principales: Osrodek, Marta, Hartman, Mariusz L., Czyz, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747123/
https://www.ncbi.nlm.nih.gov/pubmed/31461993
http://dx.doi.org/10.3390/ijms20174203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747123/
https://www.ncbi.nlm.nih.gov/pubmed/31461993
http://dx.doi.org/10.3390/ijms20174203

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