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Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System
Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747127/ https://www.ncbi.nlm.nih.gov/pubmed/31461876 http://dx.doi.org/10.3390/ijms20174192 |
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author | Sundaram, Venkat Krishnan Massaad, Charbel Grenier, Julien |
author_facet | Sundaram, Venkat Krishnan Massaad, Charbel Grenier, Julien |
author_sort | Sundaram, Venkat Krishnan |
collection | PubMed |
description | Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelination, and they regulate ER stress in sensory neurons. Furthermore, LXR stimulation has a positive impact on abrogating the effects of diabetic peripheral neuropathy and obesity-induced allodynia in the Peripheral Nervous System (PNS). This review details these findings and addresses certain important questions that are yet to be answered. The potential roles of LXRs in different cells of the PNS are speculated based on existing knowledge. The review also aims to provide important perspectives for further research in elucidating the role of LXRs and assessing the potential of LXR based therapies to combat pathologies of the Peripheral Nervous System. |
format | Online Article Text |
id | pubmed-6747127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67471272019-09-27 Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System Sundaram, Venkat Krishnan Massaad, Charbel Grenier, Julien Int J Mol Sci Review Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelination, and they regulate ER stress in sensory neurons. Furthermore, LXR stimulation has a positive impact on abrogating the effects of diabetic peripheral neuropathy and obesity-induced allodynia in the Peripheral Nervous System (PNS). This review details these findings and addresses certain important questions that are yet to be answered. The potential roles of LXRs in different cells of the PNS are speculated based on existing knowledge. The review also aims to provide important perspectives for further research in elucidating the role of LXRs and assessing the potential of LXR based therapies to combat pathologies of the Peripheral Nervous System. MDPI 2019-08-27 /pmc/articles/PMC6747127/ /pubmed/31461876 http://dx.doi.org/10.3390/ijms20174192 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sundaram, Venkat Krishnan Massaad, Charbel Grenier, Julien Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title | Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title_full | Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title_fullStr | Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title_full_unstemmed | Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title_short | Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System |
title_sort | liver x receptors and their implications in the physiology and pathology of the peripheral nervous system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747127/ https://www.ncbi.nlm.nih.gov/pubmed/31461876 http://dx.doi.org/10.3390/ijms20174192 |
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