Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor

The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood–brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor o...

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Detalles Bibliográficos
Autores principales: Russo, Alexandra, Paret, Claudia, Alt, Francesca, Burhenne, Jürgen, Fresnais, Margaux, Wagner, Wolfgang, Glaser, Martin, Bender, Hannah, Huprich, Sabrina, Harter, Patrick N., Filipski, Katharina, Lehmann, Nadine, Backes, Nora, Roth, Lea, Seidmann, Larissa, Sommer, Clemens, Brockmann, Marc A., Pietsch, Torsten, Neu, Marie A., Wingerter, Arthur, Faber, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747232/
https://www.ncbi.nlm.nih.gov/pubmed/31480400
http://dx.doi.org/10.3390/ijms20174267

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