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Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preven...

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Autores principales: Dallio, Marcello, Diano, Nadia, Masarone, Mario, Gravina, Antonietta Gerarda, Patanè, Vittorio, Romeo, Mario, Di Sarno, Rosa, Errico, Sonia, Nicolucci, Carla, Abenavoli, Ludovico, Scarpellini, Emidio, Boccuto, Luigi, Persico, Marcello, Loguercio, Carmelina, Federico, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747307/
https://www.ncbi.nlm.nih.gov/pubmed/31466361
http://dx.doi.org/10.3390/ijerph16173134
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author Dallio, Marcello
Diano, Nadia
Masarone, Mario
Gravina, Antonietta Gerarda
Patanè, Vittorio
Romeo, Mario
Di Sarno, Rosa
Errico, Sonia
Nicolucci, Carla
Abenavoli, Ludovico
Scarpellini, Emidio
Boccuto, Luigi
Persico, Marcello
Loguercio, Carmelina
Federico, Alessandro
author_facet Dallio, Marcello
Diano, Nadia
Masarone, Mario
Gravina, Antonietta Gerarda
Patanè, Vittorio
Romeo, Mario
Di Sarno, Rosa
Errico, Sonia
Nicolucci, Carla
Abenavoli, Ludovico
Scarpellini, Emidio
Boccuto, Luigi
Persico, Marcello
Loguercio, Carmelina
Federico, Alessandro
author_sort Dallio, Marcello
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution.
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spelling pubmed-67473072019-09-27 Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease Dallio, Marcello Diano, Nadia Masarone, Mario Gravina, Antonietta Gerarda Patanè, Vittorio Romeo, Mario Di Sarno, Rosa Errico, Sonia Nicolucci, Carla Abenavoli, Ludovico Scarpellini, Emidio Boccuto, Luigi Persico, Marcello Loguercio, Carmelina Federico, Alessandro Int J Environ Res Public Health Review Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution. MDPI 2019-08-28 2019-09 /pmc/articles/PMC6747307/ /pubmed/31466361 http://dx.doi.org/10.3390/ijerph16173134 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dallio, Marcello
Diano, Nadia
Masarone, Mario
Gravina, Antonietta Gerarda
Patanè, Vittorio
Romeo, Mario
Di Sarno, Rosa
Errico, Sonia
Nicolucci, Carla
Abenavoli, Ludovico
Scarpellini, Emidio
Boccuto, Luigi
Persico, Marcello
Loguercio, Carmelina
Federico, Alessandro
Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title_full Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title_fullStr Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title_short Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
title_sort chemical effect of bisphenol a on non-alcoholic fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747307/
https://www.ncbi.nlm.nih.gov/pubmed/31466361
http://dx.doi.org/10.3390/ijerph16173134
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