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Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study

African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the diff...

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Autores principales: Li, Chengchen, Wang, Zeyuan, Hardy, Theresa, Huang, Yunfeng, Hui, Qin, Crusto, Cindy A., Wright, Michelle L., Taylor, Jacquelyn Y., Sun, Yan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747309/
https://www.ncbi.nlm.nih.gov/pubmed/31480455
http://dx.doi.org/10.3390/ijms20174273
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author Li, Chengchen
Wang, Zeyuan
Hardy, Theresa
Huang, Yunfeng
Hui, Qin
Crusto, Cindy A.
Wright, Michelle L.
Taylor, Jacquelyn Y.
Sun, Yan V.
author_facet Li, Chengchen
Wang, Zeyuan
Hardy, Theresa
Huang, Yunfeng
Hui, Qin
Crusto, Cindy A.
Wright, Michelle L.
Taylor, Jacquelyn Y.
Sun, Yan V.
author_sort Li, Chengchen
collection PubMed
description African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m(2) increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women.
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spelling pubmed-67473092019-09-27 Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study Li, Chengchen Wang, Zeyuan Hardy, Theresa Huang, Yunfeng Hui, Qin Crusto, Cindy A. Wright, Michelle L. Taylor, Jacquelyn Y. Sun, Yan V. Int J Mol Sci Article African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m(2) increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women. MDPI 2019-08-31 /pmc/articles/PMC6747309/ /pubmed/31480455 http://dx.doi.org/10.3390/ijms20174273 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Chengchen
Wang, Zeyuan
Hardy, Theresa
Huang, Yunfeng
Hui, Qin
Crusto, Cindy A.
Wright, Michelle L.
Taylor, Jacquelyn Y.
Sun, Yan V.
Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title_full Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title_fullStr Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title_full_unstemmed Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title_short Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study
title_sort association of obesity with dna methylation age acceleration in african american mothers from the intergen study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747309/
https://www.ncbi.nlm.nih.gov/pubmed/31480455
http://dx.doi.org/10.3390/ijms20174273
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