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Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children

Child blood lead concentrations have been associated with measures of immune dysregulation in nationally representative study samples. However, response to vaccination—often considered the gold standard in immunotoxicity testing—has not been examined in relation to typical background lead concentrat...

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Autores principales: Jusko, Todd A., Singh, Kyra, Greener, Elizabeth A., Oktapodas Feiler, Marina, Thevenet-Morrison, Kelly, Lawrence, B. Paige, Wright, Robert O., Thurston, Sally W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747326/
https://www.ncbi.nlm.nih.gov/pubmed/31443341
http://dx.doi.org/10.3390/ijerph16173035
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author Jusko, Todd A.
Singh, Kyra
Greener, Elizabeth A.
Oktapodas Feiler, Marina
Thevenet-Morrison, Kelly
Lawrence, B. Paige
Wright, Robert O.
Thurston, Sally W.
author_facet Jusko, Todd A.
Singh, Kyra
Greener, Elizabeth A.
Oktapodas Feiler, Marina
Thevenet-Morrison, Kelly
Lawrence, B. Paige
Wright, Robert O.
Thurston, Sally W.
author_sort Jusko, Todd A.
collection PubMed
description Child blood lead concentrations have been associated with measures of immune dysregulation in nationally representative study samples. However, response to vaccination—often considered the gold standard in immunotoxicity testing—has not been examined in relation to typical background lead concentrations common among U.S. children. The present study estimated the association between blood lead concentrations and antigen-specific antibody levels to measles, mumps, and rubella in a nationally representative sample of 7005 U.S. children aged 6–17 years. Data from the 1999–2004 cycles of the National Health and Nutrition Examination Survey (NHANES) were used. In the adjusted models, children with blood lead concentrations between 1 and 5 µg/dL had an 11% lower anti-measles (95% CI: −16, −5) and a 6% lower anti-mumps antibody level (95% CI: −11, −2) compared to children with blood lead concentrations <1 µg/dL. The odds of a seronegative anti-measles antibody level was approximately two-fold greater for children with blood lead concentrations between 1 and 5 µg/dL compared to children with blood lead concentrations <1 µg/dL (OR = 2.0, 95% CI: 1.4, 3.1). The adverse associations observed in the present study provide further evidence of potential immunosuppression at blood lead concentrations <5 µg/dL, the present Centers for Disease Control and Prevention action level.
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spelling pubmed-67473262019-09-27 Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children Jusko, Todd A. Singh, Kyra Greener, Elizabeth A. Oktapodas Feiler, Marina Thevenet-Morrison, Kelly Lawrence, B. Paige Wright, Robert O. Thurston, Sally W. Int J Environ Res Public Health Communication Child blood lead concentrations have been associated with measures of immune dysregulation in nationally representative study samples. However, response to vaccination—often considered the gold standard in immunotoxicity testing—has not been examined in relation to typical background lead concentrations common among U.S. children. The present study estimated the association between blood lead concentrations and antigen-specific antibody levels to measles, mumps, and rubella in a nationally representative sample of 7005 U.S. children aged 6–17 years. Data from the 1999–2004 cycles of the National Health and Nutrition Examination Survey (NHANES) were used. In the adjusted models, children with blood lead concentrations between 1 and 5 µg/dL had an 11% lower anti-measles (95% CI: −16, −5) and a 6% lower anti-mumps antibody level (95% CI: −11, −2) compared to children with blood lead concentrations <1 µg/dL. The odds of a seronegative anti-measles antibody level was approximately two-fold greater for children with blood lead concentrations between 1 and 5 µg/dL compared to children with blood lead concentrations <1 µg/dL (OR = 2.0, 95% CI: 1.4, 3.1). The adverse associations observed in the present study provide further evidence of potential immunosuppression at blood lead concentrations <5 µg/dL, the present Centers for Disease Control and Prevention action level. MDPI 2019-08-22 2019-09 /pmc/articles/PMC6747326/ /pubmed/31443341 http://dx.doi.org/10.3390/ijerph16173035 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Jusko, Todd A.
Singh, Kyra
Greener, Elizabeth A.
Oktapodas Feiler, Marina
Thevenet-Morrison, Kelly
Lawrence, B. Paige
Wright, Robert O.
Thurston, Sally W.
Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title_full Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title_fullStr Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title_full_unstemmed Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title_short Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
title_sort blood lead concentrations and antibody levels to measles, mumps, and rubella among u.s. children
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747326/
https://www.ncbi.nlm.nih.gov/pubmed/31443341
http://dx.doi.org/10.3390/ijerph16173035
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