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Hypoxic Regulation of Neutrophils in Cancer
Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regul...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747474/ https://www.ncbi.nlm.nih.gov/pubmed/31461847 http://dx.doi.org/10.3390/ijms20174189 |
| _version_ | 1783451907110469632 |
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| author | Triner, Daniel Shah, Yatrik M. |
| author_facet | Triner, Daniel Shah, Yatrik M. |
| author_sort | Triner, Daniel |
| collection | PubMed |
| description | Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer. |
| format | Online Article Text |
| id | pubmed-6747474 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67474742019-09-27 Hypoxic Regulation of Neutrophils in Cancer Triner, Daniel Shah, Yatrik M. Int J Mol Sci Review Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer. MDPI 2019-08-27 /pmc/articles/PMC6747474/ /pubmed/31461847 http://dx.doi.org/10.3390/ijms20174189 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Triner, Daniel Shah, Yatrik M. Hypoxic Regulation of Neutrophils in Cancer |
| title | Hypoxic Regulation of Neutrophils in Cancer |
| title_full | Hypoxic Regulation of Neutrophils in Cancer |
| title_fullStr | Hypoxic Regulation of Neutrophils in Cancer |
| title_full_unstemmed | Hypoxic Regulation of Neutrophils in Cancer |
| title_short | Hypoxic Regulation of Neutrophils in Cancer |
| title_sort | hypoxic regulation of neutrophils in cancer |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747474/ https://www.ncbi.nlm.nih.gov/pubmed/31461847 http://dx.doi.org/10.3390/ijms20174189 |
| work_keys_str_mv | AT trinerdaniel hypoxicregulationofneutrophilsincancer AT shahyatrikm hypoxicregulationofneutrophilsincancer |