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Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents

Whole exome analyses have identified a number of genes associated with autism spectrum disorder (ASD) and ASD-related syndromes. These genes encode key regulators of synaptogenesis, synaptic plasticity, cytoskeleton dynamics, protein synthesis and degradation, chromatin remodeling, transcription, an...

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Autores principales: Ueoka, Ibuki, Pham, Hang Thi Nguyet, Matsumoto, Kinzo, Yamaguchi, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747505/
https://www.ncbi.nlm.nih.gov/pubmed/31438473
http://dx.doi.org/10.3390/ijms20174071
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author Ueoka, Ibuki
Pham, Hang Thi Nguyet
Matsumoto, Kinzo
Yamaguchi, Masamitsu
author_facet Ueoka, Ibuki
Pham, Hang Thi Nguyet
Matsumoto, Kinzo
Yamaguchi, Masamitsu
author_sort Ueoka, Ibuki
collection PubMed
description Whole exome analyses have identified a number of genes associated with autism spectrum disorder (ASD) and ASD-related syndromes. These genes encode key regulators of synaptogenesis, synaptic plasticity, cytoskeleton dynamics, protein synthesis and degradation, chromatin remodeling, transcription, and lipid homeostasis. Furthermore, in silico studies suggest complex regulatory networks among these genes. Drosophila is a useful genetic model system for studies of ASD and ASD-related syndromes to clarify the in vivo roles of ASD-associated genes and the complex gene regulatory networks operating in the pathogenesis of ASD and ASD-related syndromes. In this review, we discuss what we have learned from studies with vertebrate models, mostly mouse models. We then highlight studies with Drosophila models. We also discuss future developments in the related field.
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spelling pubmed-67475052019-09-27 Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents Ueoka, Ibuki Pham, Hang Thi Nguyet Matsumoto, Kinzo Yamaguchi, Masamitsu Int J Mol Sci Review Whole exome analyses have identified a number of genes associated with autism spectrum disorder (ASD) and ASD-related syndromes. These genes encode key regulators of synaptogenesis, synaptic plasticity, cytoskeleton dynamics, protein synthesis and degradation, chromatin remodeling, transcription, and lipid homeostasis. Furthermore, in silico studies suggest complex regulatory networks among these genes. Drosophila is a useful genetic model system for studies of ASD and ASD-related syndromes to clarify the in vivo roles of ASD-associated genes and the complex gene regulatory networks operating in the pathogenesis of ASD and ASD-related syndromes. In this review, we discuss what we have learned from studies with vertebrate models, mostly mouse models. We then highlight studies with Drosophila models. We also discuss future developments in the related field. MDPI 2019-08-21 /pmc/articles/PMC6747505/ /pubmed/31438473 http://dx.doi.org/10.3390/ijms20174071 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ueoka, Ibuki
Pham, Hang Thi Nguyet
Matsumoto, Kinzo
Yamaguchi, Masamitsu
Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title_full Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title_fullStr Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title_full_unstemmed Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title_short Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents
title_sort autism spectrum disorder-related syndromes: modeling with drosophila and rodents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747505/
https://www.ncbi.nlm.nih.gov/pubmed/31438473
http://dx.doi.org/10.3390/ijms20174071
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