Cargando…

3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds

This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)–calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike convention...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Jae-Won, Maeng, Woo-Youl, Koh, Young-Hag, Lee, Hyun, Kim, Hyoun-Ee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747617/
https://www.ncbi.nlm.nih.gov/pubmed/31438474
http://dx.doi.org/10.3390/ma12172650
_version_ 1783451940507615232
author Choi, Jae-Won
Maeng, Woo-Youl
Koh, Young-Hag
Lee, Hyun
Kim, Hyoun-Ee
author_facet Choi, Jae-Won
Maeng, Woo-Youl
Koh, Young-Hag
Lee, Hyun
Kim, Hyoun-Ee
author_sort Choi, Jae-Won
collection PubMed
description This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)–calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL–CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL–CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL–CaP composite scaffolds were substantially improved.
format Online
Article
Text
id pubmed-6747617
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67476172019-09-27 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds Choi, Jae-Won Maeng, Woo-Youl Koh, Young-Hag Lee, Hyun Kim, Hyoun-Ee Materials (Basel) Article This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)–calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL–CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL–CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL–CaP composite scaffolds were substantially improved. MDPI 2019-08-21 /pmc/articles/PMC6747617/ /pubmed/31438474 http://dx.doi.org/10.3390/ma12172650 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Jae-Won
Maeng, Woo-Youl
Koh, Young-Hag
Lee, Hyun
Kim, Hyoun-Ee
3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title_full 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title_fullStr 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title_full_unstemmed 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title_short 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds
title_sort 3d plotting using camphene as pore-regulating agent to produce hierarchical macro/micro-porous poly(ε-caprolactone)/calcium phosphate composite scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747617/
https://www.ncbi.nlm.nih.gov/pubmed/31438474
http://dx.doi.org/10.3390/ma12172650
work_keys_str_mv AT choijaewon 3dplottingusingcampheneasporeregulatingagenttoproducehierarchicalmacromicroporouspolyecaprolactonecalciumphosphatecompositescaffolds
AT maengwooyoul 3dplottingusingcampheneasporeregulatingagenttoproducehierarchicalmacromicroporouspolyecaprolactonecalciumphosphatecompositescaffolds
AT kohyounghag 3dplottingusingcampheneasporeregulatingagenttoproducehierarchicalmacromicroporouspolyecaprolactonecalciumphosphatecompositescaffolds
AT leehyun 3dplottingusingcampheneasporeregulatingagenttoproducehierarchicalmacromicroporouspolyecaprolactonecalciumphosphatecompositescaffolds
AT kimhyounee 3dplottingusingcampheneasporeregulatingagenttoproducehierarchicalmacromicroporouspolyecaprolactonecalciumphosphatecompositescaffolds