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Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol
INTRODUCTION: The global burden of dementia is rising, emphasising the urgent need to develop effective approaches to risk reduction. Recent evidence suggests that common bacterial infections may increase the risk of dementia, however the magnitude and timing of the association as well as the patien...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747671/ https://www.ncbi.nlm.nih.gov/pubmed/31515431 http://dx.doi.org/10.1136/bmjopen-2019-030874 |
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author | Muzambi, Rutendo Bhaskaran, Krishnan Brayne, Carol Smeeth, Liam Warren-Gash, Charlotte |
author_facet | Muzambi, Rutendo Bhaskaran, Krishnan Brayne, Carol Smeeth, Liam Warren-Gash, Charlotte |
author_sort | Muzambi, Rutendo |
collection | PubMed |
description | INTRODUCTION: The global burden of dementia is rising, emphasising the urgent need to develop effective approaches to risk reduction. Recent evidence suggests that common bacterial infections may increase the risk of dementia, however the magnitude and timing of the association as well as the patient groups affected remains unclear. We will review existing evidence of the association between common bacterial infections and incident cognitive decline or dementia. METHODS AND ANALYSIS: We will conduct a comprehensive search of published and grey literature from inception to 18 March 2019. The following electronic databases will be searched; MEDLINE, EMBASE, Global health, PsycINFO, Web of Science, Scopus, Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, Open Grey and the British Library of Electronic Theses databases. There will be no restrictions on the date, language or geographical location of the studies. We will include longitudinal studies with a common clinically symptomatic bacterial infection as an exposure and incident cognitive decline or dementia as an outcome. Study selection, data extraction and risk of bias will be performed independently by two researchers. We will assess the risk of bias using the Cochrane collaboration approach. The overall quality of the studies will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations criteria. We will explore the heterogeneity of relevant studies and, if feasible, a meta-analysis will be performed, otherwise we will present a narrative synthesis. We will group the results by exposure and outcome definitions and differences will be described by subgroups and outcomes. ETHICS AND DISSEMINATION: Ethical approval will not be required as this is a systematic review of existing research in the public domain. Results will be disseminated in a peer-reviewed journal and presented at national and international meetings and conferences. PROSPERO REGISTRATION NUMBER: CRD42018119294. |
format | Online Article Text |
id | pubmed-6747671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67476712019-09-27 Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol Muzambi, Rutendo Bhaskaran, Krishnan Brayne, Carol Smeeth, Liam Warren-Gash, Charlotte BMJ Open Epidemiology INTRODUCTION: The global burden of dementia is rising, emphasising the urgent need to develop effective approaches to risk reduction. Recent evidence suggests that common bacterial infections may increase the risk of dementia, however the magnitude and timing of the association as well as the patient groups affected remains unclear. We will review existing evidence of the association between common bacterial infections and incident cognitive decline or dementia. METHODS AND ANALYSIS: We will conduct a comprehensive search of published and grey literature from inception to 18 March 2019. The following electronic databases will be searched; MEDLINE, EMBASE, Global health, PsycINFO, Web of Science, Scopus, Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, Open Grey and the British Library of Electronic Theses databases. There will be no restrictions on the date, language or geographical location of the studies. We will include longitudinal studies with a common clinically symptomatic bacterial infection as an exposure and incident cognitive decline or dementia as an outcome. Study selection, data extraction and risk of bias will be performed independently by two researchers. We will assess the risk of bias using the Cochrane collaboration approach. The overall quality of the studies will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations criteria. We will explore the heterogeneity of relevant studies and, if feasible, a meta-analysis will be performed, otherwise we will present a narrative synthesis. We will group the results by exposure and outcome definitions and differences will be described by subgroups and outcomes. ETHICS AND DISSEMINATION: Ethical approval will not be required as this is a systematic review of existing research in the public domain. Results will be disseminated in a peer-reviewed journal and presented at national and international meetings and conferences. PROSPERO REGISTRATION NUMBER: CRD42018119294. BMJ Publishing Group 2019-09-12 /pmc/articles/PMC6747671/ /pubmed/31515431 http://dx.doi.org/10.1136/bmjopen-2019-030874 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Muzambi, Rutendo Bhaskaran, Krishnan Brayne, Carol Smeeth, Liam Warren-Gash, Charlotte Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title | Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title_full | Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title_fullStr | Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title_full_unstemmed | Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title_short | Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
title_sort | common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747671/ https://www.ncbi.nlm.nih.gov/pubmed/31515431 http://dx.doi.org/10.1136/bmjopen-2019-030874 |
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